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The Role of Vitamin D Deficiency and Vitamin D Receptor Genotypes on the Degree of Collateralization in Patients with Suspected Coronary Artery Disease
Joint Authors
Shirzad, Mahmood
Mirzaei, Khadijeh
Eshaghi, Seyede Mahdieh
Hossein-Nezhad, Arash
Curletto, Bryon
Maghbooli, Zhila
Chen, Tai C.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We determined the association of vitamin D deficiency and the FokI polymorphism of the vitamin D receptor (VDR) gene in 760 patients who underwent angiography due to suspected coronary artery disease (CAD).
Angiography and the Rentrop scoring system were used to classify the severity of CAD in each patient and to grade the extent of collateral development, respectively.
Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to determine the FokI VDR gene polymorphism.
The prevalence of severe vitamin D deficiency (serum 25(OH)D < 10 ng/mL) was significantly higher in patients with at least one stenotic coronary artery compared to those without any stenotic coronary arteries.
Severe vitamin D deficiency was not independently associated with collateralization, but it was significantly associated with the VDR genotypes.
In turn, VDR genotype was independently associated with the degree of collateralization; the Rentrop scores were the highest in FF, intermediate in Ff, and the lowest in the ff genotype.
The results show that FokI polymorphism is independently associated with collateralization.
Additionally, vitamin D deficiency is more prevalent in patients with CAD that may result from FokI polymorphism.
Therefore, maintaining a normal vitamin D status should be a high priority for patients with CAD.
American Psychological Association (APA)
Hossein-Nezhad, Arash& Eshaghi, Seyede Mahdieh& Maghbooli, Zhila& Mirzaei, Khadijeh& Shirzad, Mahmood& Curletto, Bryon…[et al.]. 2014. The Role of Vitamin D Deficiency and Vitamin D Receptor Genotypes on the Degree of Collateralization in Patients with Suspected Coronary Artery Disease. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-461850
Modern Language Association (MLA)
Hossein-Nezhad, Arash…[et al.]. The Role of Vitamin D Deficiency and Vitamin D Receptor Genotypes on the Degree of Collateralization in Patients with Suspected Coronary Artery Disease. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-461850
American Medical Association (AMA)
Hossein-Nezhad, Arash& Eshaghi, Seyede Mahdieh& Maghbooli, Zhila& Mirzaei, Khadijeh& Shirzad, Mahmood& Curletto, Bryon…[et al.]. The Role of Vitamin D Deficiency and Vitamin D Receptor Genotypes on the Degree of Collateralization in Patients with Suspected Coronary Artery Disease. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-461850
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461850