Enhanced Healing of Diabetic Wounds by Topical Administration of Adipose Tissue-Derived Stromal Cells Overexpressing Stromal-Derived Factor-1 : Biodistribution and Engraftment Analysis by Bioluminescent Imaging
المؤلفون المشاركون
Antonini, Annalisa
Di Rocco, Giuliana
Toietta, Gabriele
Capogrossi, Maurizio C.
Wu, Joseph C.
Gentile, Antonietta
Ceradini, Francesca
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-12-26
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الملخص EN
Chronic ulcers represent a major health problem in diabetic patients resulting in pain and discomfort.
Conventional therapy does not guarantee adequate wound repair.
In diabetes, impaired healing is partly due to poor endothelial progenitor cells mobilisation and homing, with altered levels of the chemokine stromal-derived factor-1 (SDF-1) at the wound site.
Adipose tissue-associated stromal cells (AT-SCs) can provide an accessible source of progenitor cells secreting proangiogenic factors and differentiating into endothelial-like cells.
We demonstrated that topical administration of AT-SCs genetically modified ex vivo to overexpress SDF-1, promotes wound healing into diabetic mice.
In particular, by in vivo bioluminescent imaging analysis, we monitored biodistribution and survival after transplantation of luciferase-expressing cells.
In conclusion, this study indicates the therapeutic potential of AT-SCs administration in wound healing, through cell differentiation, enhanced cellular recruitment at the wound site, and paracrine effects associated with local growth-factors production.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Di Rocco, Giuliana& Gentile, Antonietta& Antonini, Annalisa& Ceradini, Francesca& Wu, Joseph C.& Capogrossi, Maurizio C.…[et al.]. 2010. Enhanced Healing of Diabetic Wounds by Topical Administration of Adipose Tissue-Derived Stromal Cells Overexpressing Stromal-Derived Factor-1 : Biodistribution and Engraftment Analysis by Bioluminescent Imaging. Stem Cells International،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-461869
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Di Rocco, Giuliana…[et al.]. Enhanced Healing of Diabetic Wounds by Topical Administration of Adipose Tissue-Derived Stromal Cells Overexpressing Stromal-Derived Factor-1 : Biodistribution and Engraftment Analysis by Bioluminescent Imaging. Stem Cells International No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-461869
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Di Rocco, Giuliana& Gentile, Antonietta& Antonini, Annalisa& Ceradini, Francesca& Wu, Joseph C.& Capogrossi, Maurizio C.…[et al.]. Enhanced Healing of Diabetic Wounds by Topical Administration of Adipose Tissue-Derived Stromal Cells Overexpressing Stromal-Derived Factor-1 : Biodistribution and Engraftment Analysis by Bioluminescent Imaging. Stem Cells International. 2010. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-461869
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-461869
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر