Phytochemical Prospection and Modulation of Antibiotic Activity In Vitro by Lippia origanoides H.B.K. in Methicillin Resistant Staphylococcus aureus
المؤلفون المشاركون
Douglas Melo Coutinho, Henrique
Medeiros Barreto, Humberto
Cavalcanti dos Santos, Bernadete Helena
Pereira de Oliveira, Aldeídia
Oliveira de Sousa, Taciana
Cerqueira Fontinele, Filipe
de Abreu, Aislan Pereira Lira
Lopes Citó, Antonia Maria das Graças
Alves Carvalho da Silva, Romezio
Dantas Lopes, José Arimateia
Arcanjo, Daniel Dias Rufino
Freire de Medeiros, Maria das Graças
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-10
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The Lippia origanoides H.B.K.
ethanol extract (LOEE) and hexane (LOHEX), dichloromethane (LODCM), and ethyl acetate (LOEA) fractions were tested for their antimicrobial activity alone or in combination with antibiotics against a methicillin resistant Staphylococcus aureus (MRSA) strain.
The natural products did not show antimicrobial activity against multidrug resistant strain at the clinically significant concentrations tested.
However, a modulatory effect in the antibacterial activity of the neomycin and amikacin was verified when LOEE, LOHEX and LODCM were added to the growth medium at subinhibitory concentrations.
A similar modulation was found when the natural products were changed for chlorpromazine, an inhibitor of bacterial efflux pumps, suggesting the involvement of resistance mediated by efflux system in the MRSA tested.
The fractions LOHEX and LODCM showed a modulatory activity bigger than their majority compounds (carvacrol, thymol, and naringenin), indicating that this activity is not due to their majority compounds only, but it is probably due to a synergism between their chemical components.
These results indicate that L.
origanoides H.B.K.
can be a source of phytochemicals able to modify the phenotype of resistance to aminoglycosides in MRSA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Medeiros Barreto, Humberto& Cerqueira Fontinele, Filipe& Pereira de Oliveira, Aldeídia& Arcanjo, Daniel Dias Rufino& Cavalcanti dos Santos, Bernadete Helena& de Abreu, Aislan Pereira Lira…[et al.]. 2014. Phytochemical Prospection and Modulation of Antibiotic Activity In Vitro by Lippia origanoides H.B.K. in Methicillin Resistant Staphylococcus aureus. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-461966
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Medeiros Barreto, Humberto…[et al.]. Phytochemical Prospection and Modulation of Antibiotic Activity In Vitro by Lippia origanoides H.B.K. in Methicillin Resistant Staphylococcus aureus. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-461966
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Medeiros Barreto, Humberto& Cerqueira Fontinele, Filipe& Pereira de Oliveira, Aldeídia& Arcanjo, Daniel Dias Rufino& Cavalcanti dos Santos, Bernadete Helena& de Abreu, Aislan Pereira Lira…[et al.]. Phytochemical Prospection and Modulation of Antibiotic Activity In Vitro by Lippia origanoides H.B.K. in Methicillin Resistant Staphylococcus aureus. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-461966
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-461966
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر