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Phytochemical Prospection and Modulation of Antibiotic Activity In Vitro by Lippia origanoides H.B.K. in Methicillin Resistant Staphylococcus aureus
Joint Authors
Douglas Melo Coutinho, Henrique
Medeiros Barreto, Humberto
Cavalcanti dos Santos, Bernadete Helena
Pereira de Oliveira, Aldeídia
Oliveira de Sousa, Taciana
Cerqueira Fontinele, Filipe
de Abreu, Aislan Pereira Lira
Lopes Citó, Antonia Maria das Graças
Alves Carvalho da Silva, Romezio
Dantas Lopes, José Arimateia
Arcanjo, Daniel Dias Rufino
Freire de Medeiros, Maria das Graças
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The Lippia origanoides H.B.K.
ethanol extract (LOEE) and hexane (LOHEX), dichloromethane (LODCM), and ethyl acetate (LOEA) fractions were tested for their antimicrobial activity alone or in combination with antibiotics against a methicillin resistant Staphylococcus aureus (MRSA) strain.
The natural products did not show antimicrobial activity against multidrug resistant strain at the clinically significant concentrations tested.
However, a modulatory effect in the antibacterial activity of the neomycin and amikacin was verified when LOEE, LOHEX and LODCM were added to the growth medium at subinhibitory concentrations.
A similar modulation was found when the natural products were changed for chlorpromazine, an inhibitor of bacterial efflux pumps, suggesting the involvement of resistance mediated by efflux system in the MRSA tested.
The fractions LOHEX and LODCM showed a modulatory activity bigger than their majority compounds (carvacrol, thymol, and naringenin), indicating that this activity is not due to their majority compounds only, but it is probably due to a synergism between their chemical components.
These results indicate that L.
origanoides H.B.K.
can be a source of phytochemicals able to modify the phenotype of resistance to aminoglycosides in MRSA.
American Psychological Association (APA)
Medeiros Barreto, Humberto& Cerqueira Fontinele, Filipe& Pereira de Oliveira, Aldeídia& Arcanjo, Daniel Dias Rufino& Cavalcanti dos Santos, Bernadete Helena& de Abreu, Aislan Pereira Lira…[et al.]. 2014. Phytochemical Prospection and Modulation of Antibiotic Activity In Vitro by Lippia origanoides H.B.K. in Methicillin Resistant Staphylococcus aureus. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-461966
Modern Language Association (MLA)
Medeiros Barreto, Humberto…[et al.]. Phytochemical Prospection and Modulation of Antibiotic Activity In Vitro by Lippia origanoides H.B.K. in Methicillin Resistant Staphylococcus aureus. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-461966
American Medical Association (AMA)
Medeiros Barreto, Humberto& Cerqueira Fontinele, Filipe& Pereira de Oliveira, Aldeídia& Arcanjo, Daniel Dias Rufino& Cavalcanti dos Santos, Bernadete Helena& de Abreu, Aislan Pereira Lira…[et al.]. Phytochemical Prospection and Modulation of Antibiotic Activity In Vitro by Lippia origanoides H.B.K. in Methicillin Resistant Staphylococcus aureus. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-461966
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461966