Assessment of Clinical Diagnosis, Microscopy, Rapid Diagnostic Tests, and Polymerase Chain Reaction in the Diagnosis of Plasmodium falciparum in Nigeria
المؤلفون المشاركون
Olowe, Olugbenga Adekunle
Ojurongbe, Olusola
Taiwo, Sunday Samuel
Ojurongbe, Taiwo Adetola
Bolaji, Oloyede Samuel
Adegbosin, Olunike Olayeni
Adeyeba, Oluwaseyi Adegboyega
Alli, Oyebode Armstrong Terry
المصدر
Malaria Research and Treatment
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-24
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
This study compares the performance of clinical diagnosis and three laboratory diagnostic methods (thick film microscopy (TFM), rapid diagnostic test (RDT), and polymerase chain reaction (PCR)) for the diagnosis of Plasmodium falciparum in Nigeria.
Using clinical criteria, 217 children were recruited into the study out of which 106 (48.8%) were positive by TFM, 84 (38.7%) by RDT, and 125 (57.6%) by PCR.
Using a composite reference method generated from the three diagnostic methods, 71 (32.7%) patients were found to be truly infected and 90 (41.5%) truly uninfected, while 56 (25.8%) were misidentified as infected or noninfected.
When each of the 3 diagnostic methods was compared with the composite reference, PCR had sensitivity of 97.3%, specificity of 62.5%, positive predictive value (PPV) of 56.8%, and negative predictive value (NPV) of 97.8%; microscopy had sensitivity of 77.2%, specificity of 72%, PPV of 66.9%, and NPV of 81.1%, while RDT had sensitivity of 62.3%, specificity of 87.4%, PPV of 67.7%, and NPV of 84.5%.
PCR test performed best among the three methods followed by TFM and RDT in that order.
The result of this study shows that clinical diagnosis cannot be relied upon for accurate diagnosis of P.
falciparum in endemic areas.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ojurongbe, Olusola& Adegbosin, Olunike Olayeni& Taiwo, Sunday Samuel& Alli, Oyebode Armstrong Terry& Olowe, Olugbenga Adekunle& Ojurongbe, Taiwo Adetola…[et al.]. 2013. Assessment of Clinical Diagnosis, Microscopy, Rapid Diagnostic Tests, and Polymerase Chain Reaction in the Diagnosis of Plasmodium falciparum in Nigeria. Malaria Research and Treatment،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-462221
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ojurongbe, Olusola…[et al.]. Assessment of Clinical Diagnosis, Microscopy, Rapid Diagnostic Tests, and Polymerase Chain Reaction in the Diagnosis of Plasmodium falciparum in Nigeria. Malaria Research and Treatment No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-462221
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ojurongbe, Olusola& Adegbosin, Olunike Olayeni& Taiwo, Sunday Samuel& Alli, Oyebode Armstrong Terry& Olowe, Olugbenga Adekunle& Ojurongbe, Taiwo Adetola…[et al.]. Assessment of Clinical Diagnosis, Microscopy, Rapid Diagnostic Tests, and Polymerase Chain Reaction in the Diagnosis of Plasmodium falciparum in Nigeria. Malaria Research and Treatment. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-462221
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-462221
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر