Systemic Oxidative Stress and Conversion to Dementia of Elderly Patients with Mild Cognitive Impairment
المؤلفون المشاركون
Cremonini, Eleonora
Zuliani, Giovanni
Romani, Arianna
Bosi, Cristina
Bergamini, Carlo M.
Magon, Stefania
Cervellati, Carlo
Pilotto, Alberto
Seripa, Davide
Giuseppe, Valacchi
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-12
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Mild cognitive impairment (MCI) is regarded as a prodromal phase of late onset Alzheimer’s disease (LOAD).
It has been proposed that oxidative stress (OxS) might be implicated in the pathogenesis of LOAD.
The aim of this study was to investigate whether a redox imbalance measured as serum level of hydroperoxides (i.e., by-products of lipid peroxidation) and/or serum antioxidant capacity might be predictive of the clinical progression of MCI to LOAD.
The levels of these two markers were measured in 111 patients with MCI (follow-up: 2.0 ± 0.6 years), 105 patients with LOAD, and 118 nondemented healthy controls.
Multivariate analysis adjusted for potential confounding factors, including age, gender, smoking, and comorbidities, showed a significant increase (P<0.05) in baseline levels of OxS in MCI and LOAD as compared to cognitive healthy controls.
No differences in either of OxS markers were found by comparing MCI patients who converted (n = 29) or not converted (n = 82) to LOAD.
Overall, these results suggest that systemic OxS might be a precocious feature of MCI and LOAD.
However, the role of OxS as an early prognostic marker of progression to LOAD needs further investigations.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cervellati, Carlo& Romani, Arianna& Seripa, Davide& Cremonini, Eleonora& Bosi, Cristina& Magon, Stefania…[et al.]. 2014. Systemic Oxidative Stress and Conversion to Dementia of Elderly Patients with Mild Cognitive Impairment. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-462383
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cervellati, Carlo…[et al.]. Systemic Oxidative Stress and Conversion to Dementia of Elderly Patients with Mild Cognitive Impairment. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-462383
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cervellati, Carlo& Romani, Arianna& Seripa, Davide& Cremonini, Eleonora& Bosi, Cristina& Magon, Stefania…[et al.]. Systemic Oxidative Stress and Conversion to Dementia of Elderly Patients with Mild Cognitive Impairment. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-462383
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-462383
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر