Systemic Oxidative Stress and Conversion to Dementia of Elderly Patients with Mild Cognitive Impairment
Joint Authors
Cremonini, Eleonora
Zuliani, Giovanni
Romani, Arianna
Bosi, Cristina
Bergamini, Carlo M.
Magon, Stefania
Cervellati, Carlo
Pilotto, Alberto
Seripa, Davide
Giuseppe, Valacchi
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Mild cognitive impairment (MCI) is regarded as a prodromal phase of late onset Alzheimer’s disease (LOAD).
It has been proposed that oxidative stress (OxS) might be implicated in the pathogenesis of LOAD.
The aim of this study was to investigate whether a redox imbalance measured as serum level of hydroperoxides (i.e., by-products of lipid peroxidation) and/or serum antioxidant capacity might be predictive of the clinical progression of MCI to LOAD.
The levels of these two markers were measured in 111 patients with MCI (follow-up: 2.0 ± 0.6 years), 105 patients with LOAD, and 118 nondemented healthy controls.
Multivariate analysis adjusted for potential confounding factors, including age, gender, smoking, and comorbidities, showed a significant increase (P<0.05) in baseline levels of OxS in MCI and LOAD as compared to cognitive healthy controls.
No differences in either of OxS markers were found by comparing MCI patients who converted (n = 29) or not converted (n = 82) to LOAD.
Overall, these results suggest that systemic OxS might be a precocious feature of MCI and LOAD.
However, the role of OxS as an early prognostic marker of progression to LOAD needs further investigations.
American Psychological Association (APA)
Cervellati, Carlo& Romani, Arianna& Seripa, Davide& Cremonini, Eleonora& Bosi, Cristina& Magon, Stefania…[et al.]. 2014. Systemic Oxidative Stress and Conversion to Dementia of Elderly Patients with Mild Cognitive Impairment. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-462383
Modern Language Association (MLA)
Cervellati, Carlo…[et al.]. Systemic Oxidative Stress and Conversion to Dementia of Elderly Patients with Mild Cognitive Impairment. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-462383
American Medical Association (AMA)
Cervellati, Carlo& Romani, Arianna& Seripa, Davide& Cremonini, Eleonora& Bosi, Cristina& Magon, Stefania…[et al.]. Systemic Oxidative Stress and Conversion to Dementia of Elderly Patients with Mild Cognitive Impairment. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-462383
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462383