Enhanced Amelioration of High-Fat Diet-Induced Fatty Liver by Docosahexaenoic Acid and Lysine Supplementations
المؤلفون المشاركون
Chen, Chih-Chien
Lin, Yuan-Yu
Lin, Hsin-Yu
Chen, Yu-Jen
Mersmann, Harry J.
Ding, Shih-Torng
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-25
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Fatty liver disease is the most common pathological condition in the liver.
Here, we generated high-fat diet-(HFD-) induced nonalcoholic fatty liver disease (NAFLD) in mice and tested the effects of docosahexaenoic acid (DHA) and lysine during a four-week regular chow (RC)feeding.
Our results showed that 1% lysine and the combination of 1% lysine + 1% DHA reduced body weight.
Moreover, serum triglyceride levels were reduced by 1% DHA and 1% lysine, whereas serum alanine transaminase activity was reduced by 1% DHA and 1% DHA + 0.5% lysine.
Switching to RC reduced hepatic lipid droplet accumulation, which was further reduced by the addition of DHA or lysine.
Furthermore, the mRNA expressions of hepatic proinflammatory cytokines were suppressed by DHA and combinations of DHA + lysine, whereas the mRNA for the lipogenic gene, acetyl-CoA carboxylase 1 (ACC1), was suppressed by DHA.
In the gonadal adipose tissues, combinations of DHA and lysine inhibited mRNA expression of lipid metabolism-associated genes, including ACC1, fatty acid synthase, lipoprotein lipase, and perilipin.
In conclusion, the present study demonstrated that, in conjunction with RC-induced benefits, supplementation with DHA or lysine further ameliorated the high-fat diet-induced NAFLD and provided an alternative strategy to treat, and potentially prevent, NAFLD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lin, Hsin-Yu& Chen, Chih-Chien& Chen, Yu-Jen& Lin, Yuan-Yu& Mersmann, Harry J.& Ding, Shih-Torng. 2014. Enhanced Amelioration of High-Fat Diet-Induced Fatty Liver by Docosahexaenoic Acid and Lysine Supplementations. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-462512
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lin, Hsin-Yu…[et al.]. Enhanced Amelioration of High-Fat Diet-Induced Fatty Liver by Docosahexaenoic Acid and Lysine Supplementations. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-462512
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lin, Hsin-Yu& Chen, Chih-Chien& Chen, Yu-Jen& Lin, Yuan-Yu& Mersmann, Harry J.& Ding, Shih-Torng. Enhanced Amelioration of High-Fat Diet-Induced Fatty Liver by Docosahexaenoic Acid and Lysine Supplementations. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-462512
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-462512
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر