Enhanced Amelioration of High-Fat Diet-Induced Fatty Liver by Docosahexaenoic Acid and Lysine Supplementations
Joint Authors
Chen, Chih-Chien
Lin, Yuan-Yu
Lin, Hsin-Yu
Chen, Yu-Jen
Mersmann, Harry J.
Ding, Shih-Torng
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-25
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Fatty liver disease is the most common pathological condition in the liver.
Here, we generated high-fat diet-(HFD-) induced nonalcoholic fatty liver disease (NAFLD) in mice and tested the effects of docosahexaenoic acid (DHA) and lysine during a four-week regular chow (RC)feeding.
Our results showed that 1% lysine and the combination of 1% lysine + 1% DHA reduced body weight.
Moreover, serum triglyceride levels were reduced by 1% DHA and 1% lysine, whereas serum alanine transaminase activity was reduced by 1% DHA and 1% DHA + 0.5% lysine.
Switching to RC reduced hepatic lipid droplet accumulation, which was further reduced by the addition of DHA or lysine.
Furthermore, the mRNA expressions of hepatic proinflammatory cytokines were suppressed by DHA and combinations of DHA + lysine, whereas the mRNA for the lipogenic gene, acetyl-CoA carboxylase 1 (ACC1), was suppressed by DHA.
In the gonadal adipose tissues, combinations of DHA and lysine inhibited mRNA expression of lipid metabolism-associated genes, including ACC1, fatty acid synthase, lipoprotein lipase, and perilipin.
In conclusion, the present study demonstrated that, in conjunction with RC-induced benefits, supplementation with DHA or lysine further ameliorated the high-fat diet-induced NAFLD and provided an alternative strategy to treat, and potentially prevent, NAFLD.
American Psychological Association (APA)
Lin, Hsin-Yu& Chen, Chih-Chien& Chen, Yu-Jen& Lin, Yuan-Yu& Mersmann, Harry J.& Ding, Shih-Torng. 2014. Enhanced Amelioration of High-Fat Diet-Induced Fatty Liver by Docosahexaenoic Acid and Lysine Supplementations. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-462512
Modern Language Association (MLA)
Lin, Hsin-Yu…[et al.]. Enhanced Amelioration of High-Fat Diet-Induced Fatty Liver by Docosahexaenoic Acid and Lysine Supplementations. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-462512
American Medical Association (AMA)
Lin, Hsin-Yu& Chen, Chih-Chien& Chen, Yu-Jen& Lin, Yuan-Yu& Mersmann, Harry J.& Ding, Shih-Torng. Enhanced Amelioration of High-Fat Diet-Induced Fatty Liver by Docosahexaenoic Acid and Lysine Supplementations. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-462512
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462512