Rat Strain Differences in Susceptibility to Alcohol-Induced Chronic Liver Injury and Hepatic Insulin Resistance
المؤلفون المشاركون
de la Monte, Suzanne M.
DeNucci, Sarah M.
Carlson, Rolf I.
Longato, Lisa
Lawton, Margot
Tong, Ming
Wands, Jack R.
Setshedi, Mashiko
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-08-16
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
The finding of more severe steatohepatitis in alcohol fed Long Evans (LE) compared with Sprague Dawley (SD) and Fisher 344 (FS) rats prompted us to determine whether host factors related to alcohol metabolism, inflammation, and insulin/IGF signaling predict proneness to alcohol-mediated liver injury.
Adult FS, SD, and LE rats were fed liquid diets containing 0% or 37% (calories) ethanol for 8 weeks.
Among controls, LE rats had significantly higher ALT and reduced GAPDH relative to SD and FS rats.
Among ethanol-fed rats, despite similar blood alcohol levels, LE rats had more pronounced steatohepatitis and fibrosis, higher levels of ALT, DNA damage, pro-inflammatory cytokines, ADH, ALDH, catalase, GFAP, desmin, and collagen expression, and reduced insulin receptor binding relative to FS rats.
Ethanol-exposed SD rats had intermediate degrees of steatohepatitis, increased ALT, ADH and profibrogenesis gene expression, and suppressed insulin receptor binding and GAPDH expression, while pro-inflammatory cytokines were similarly increased as in LE rats.
Ethanol feeding in FS rats only reduced IL-6, ALDH1–3, CYP2E1, and GAPDH expression in liver.
In conclusion, susceptibility to chronic steatohepatitis may be driven by factors related to efficiency of ethanol metabolism and degree to which ethanol exposure causes hepatic insulin resistance and cytokine activation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
DeNucci, Sarah M.& Tong, Ming& Longato, Lisa& Lawton, Margot& Setshedi, Mashiko& Carlson, Rolf I.…[et al.]. 2010. Rat Strain Differences in Susceptibility to Alcohol-Induced Chronic Liver Injury and Hepatic Insulin Resistance. Gastroenterology Research and Practice،Vol. 2010, no. 2010, pp.1-16.
https://search.emarefa.net/detail/BIM-462596
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
DeNucci, Sarah M.…[et al.]. Rat Strain Differences in Susceptibility to Alcohol-Induced Chronic Liver Injury and Hepatic Insulin Resistance. Gastroenterology Research and Practice No. 2010 (2010), pp.1-16.
https://search.emarefa.net/detail/BIM-462596
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
DeNucci, Sarah M.& Tong, Ming& Longato, Lisa& Lawton, Margot& Setshedi, Mashiko& Carlson, Rolf I.…[et al.]. Rat Strain Differences in Susceptibility to Alcohol-Induced Chronic Liver Injury and Hepatic Insulin Resistance. Gastroenterology Research and Practice. 2010. Vol. 2010, no. 2010, pp.1-16.
https://search.emarefa.net/detail/BIM-462596
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-462596
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر