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Rat Strain Differences in Susceptibility to Alcohol-Induced Chronic Liver Injury and Hepatic Insulin Resistance
Joint Authors
de la Monte, Suzanne M.
DeNucci, Sarah M.
Carlson, Rolf I.
Longato, Lisa
Lawton, Margot
Tong, Ming
Wands, Jack R.
Setshedi, Mashiko
Source
Gastroenterology Research and Practice
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-16
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
The finding of more severe steatohepatitis in alcohol fed Long Evans (LE) compared with Sprague Dawley (SD) and Fisher 344 (FS) rats prompted us to determine whether host factors related to alcohol metabolism, inflammation, and insulin/IGF signaling predict proneness to alcohol-mediated liver injury.
Adult FS, SD, and LE rats were fed liquid diets containing 0% or 37% (calories) ethanol for 8 weeks.
Among controls, LE rats had significantly higher ALT and reduced GAPDH relative to SD and FS rats.
Among ethanol-fed rats, despite similar blood alcohol levels, LE rats had more pronounced steatohepatitis and fibrosis, higher levels of ALT, DNA damage, pro-inflammatory cytokines, ADH, ALDH, catalase, GFAP, desmin, and collagen expression, and reduced insulin receptor binding relative to FS rats.
Ethanol-exposed SD rats had intermediate degrees of steatohepatitis, increased ALT, ADH and profibrogenesis gene expression, and suppressed insulin receptor binding and GAPDH expression, while pro-inflammatory cytokines were similarly increased as in LE rats.
Ethanol feeding in FS rats only reduced IL-6, ALDH1–3, CYP2E1, and GAPDH expression in liver.
In conclusion, susceptibility to chronic steatohepatitis may be driven by factors related to efficiency of ethanol metabolism and degree to which ethanol exposure causes hepatic insulin resistance and cytokine activation.
American Psychological Association (APA)
DeNucci, Sarah M.& Tong, Ming& Longato, Lisa& Lawton, Margot& Setshedi, Mashiko& Carlson, Rolf I.…[et al.]. 2010. Rat Strain Differences in Susceptibility to Alcohol-Induced Chronic Liver Injury and Hepatic Insulin Resistance. Gastroenterology Research and Practice،Vol. 2010, no. 2010, pp.1-16.
https://search.emarefa.net/detail/BIM-462596
Modern Language Association (MLA)
DeNucci, Sarah M.…[et al.]. Rat Strain Differences in Susceptibility to Alcohol-Induced Chronic Liver Injury and Hepatic Insulin Resistance. Gastroenterology Research and Practice No. 2010 (2010), pp.1-16.
https://search.emarefa.net/detail/BIM-462596
American Medical Association (AMA)
DeNucci, Sarah M.& Tong, Ming& Longato, Lisa& Lawton, Margot& Setshedi, Mashiko& Carlson, Rolf I.…[et al.]. Rat Strain Differences in Susceptibility to Alcohol-Induced Chronic Liver Injury and Hepatic Insulin Resistance. Gastroenterology Research and Practice. 2010. Vol. 2010, no. 2010, pp.1-16.
https://search.emarefa.net/detail/BIM-462596
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462596