Short-Term Effect of Pitavastatin Treatment on Glucose and Lipid Metabolism and Oxidative Stress in Fasting and Postprandial State Using a Test Meal in Japanese Men
المؤلفون المشاركون
Kobayashi, Junji
Takekoshi, Noboru
Kakuda, Hirokazu
Nakatou, Mio
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-10
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Introduction.
The objective of this study was to clarify how pitavastatin affects glucose and lipid metabolism, renal function, and oxidative stress.
Methods.
Ten Japanese men (average age of 33.9 years) were orally administered 2 mg of pitavastatin for 4 weeks.
Postprandial glucose, lipoprotein metabolism, and oxidative stress markers were evaluated at 0 and 4 weeks of pitavastatin treatment (2 mg once daily) with a test meal consisting of total calories: 460 kcal, carbohydrates: 56.5 g (226 kcal), protein: 18 g (72 kcal), lipids: 18 g (162 kcal), and NaCl: 1.6 g.
Metabolic parameters were measured at 0, 60, and 120 minutes after test meal ingestion.
Results.
After administration of pitavastatin, serum total cholesterol, low-density lipoprotein cholesterol, apolipoprotein B, arachidonic acid, insulin, and adjusted urinary excretion of uric acid decreased, whereas creatinine clearance (CCr) and uric acid clearance (CUA) increased.
And postprandial versus fasting urine 8-hydroxydeoxyguanosine remained unchanged, while postprandial versus fasting isoprostane decreased after pitavastatin treatment.
Next, we compared postprandial glucose and lipid metabolism after test meal ingestion before and after pitavastatin administration.
Incremental areas under the curve significantly decreased for triglycerides (P<0.05) and remnant-like particle cholesterol (P<0.01), while those for apolipoprotein E (apoE), glucose, insulin, and high-sensitivity C-reactive protein remained unchanged.
Conclusion.
Pitavastatin improves postprandial oxidative stress along with hyperlipidemia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kakuda, Hirokazu& Kobayashi, Junji& Nakatou, Mio& Takekoshi, Noboru. 2013. Short-Term Effect of Pitavastatin Treatment on Glucose and Lipid Metabolism and Oxidative Stress in Fasting and Postprandial State Using a Test Meal in Japanese Men. Cholesterol،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-462698
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kakuda, Hirokazu…[et al.]. Short-Term Effect of Pitavastatin Treatment on Glucose and Lipid Metabolism and Oxidative Stress in Fasting and Postprandial State Using a Test Meal in Japanese Men. Cholesterol No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-462698
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kakuda, Hirokazu& Kobayashi, Junji& Nakatou, Mio& Takekoshi, Noboru. Short-Term Effect of Pitavastatin Treatment on Glucose and Lipid Metabolism and Oxidative Stress in Fasting and Postprandial State Using a Test Meal in Japanese Men. Cholesterol. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-462698
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-462698
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر