Short-Term Effect of Pitavastatin Treatment on Glucose and Lipid Metabolism and Oxidative Stress in Fasting and Postprandial State Using a Test Meal in Japanese Men
Joint Authors
Kobayashi, Junji
Takekoshi, Noboru
Kakuda, Hirokazu
Nakatou, Mio
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Introduction.
The objective of this study was to clarify how pitavastatin affects glucose and lipid metabolism, renal function, and oxidative stress.
Methods.
Ten Japanese men (average age of 33.9 years) were orally administered 2 mg of pitavastatin for 4 weeks.
Postprandial glucose, lipoprotein metabolism, and oxidative stress markers were evaluated at 0 and 4 weeks of pitavastatin treatment (2 mg once daily) with a test meal consisting of total calories: 460 kcal, carbohydrates: 56.5 g (226 kcal), protein: 18 g (72 kcal), lipids: 18 g (162 kcal), and NaCl: 1.6 g.
Metabolic parameters were measured at 0, 60, and 120 minutes after test meal ingestion.
Results.
After administration of pitavastatin, serum total cholesterol, low-density lipoprotein cholesterol, apolipoprotein B, arachidonic acid, insulin, and adjusted urinary excretion of uric acid decreased, whereas creatinine clearance (CCr) and uric acid clearance (CUA) increased.
And postprandial versus fasting urine 8-hydroxydeoxyguanosine remained unchanged, while postprandial versus fasting isoprostane decreased after pitavastatin treatment.
Next, we compared postprandial glucose and lipid metabolism after test meal ingestion before and after pitavastatin administration.
Incremental areas under the curve significantly decreased for triglycerides (P<0.05) and remnant-like particle cholesterol (P<0.01), while those for apolipoprotein E (apoE), glucose, insulin, and high-sensitivity C-reactive protein remained unchanged.
Conclusion.
Pitavastatin improves postprandial oxidative stress along with hyperlipidemia.
American Psychological Association (APA)
Kakuda, Hirokazu& Kobayashi, Junji& Nakatou, Mio& Takekoshi, Noboru. 2013. Short-Term Effect of Pitavastatin Treatment on Glucose and Lipid Metabolism and Oxidative Stress in Fasting and Postprandial State Using a Test Meal in Japanese Men. Cholesterol،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-462698
Modern Language Association (MLA)
Kakuda, Hirokazu…[et al.]. Short-Term Effect of Pitavastatin Treatment on Glucose and Lipid Metabolism and Oxidative Stress in Fasting and Postprandial State Using a Test Meal in Japanese Men. Cholesterol No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-462698
American Medical Association (AMA)
Kakuda, Hirokazu& Kobayashi, Junji& Nakatou, Mio& Takekoshi, Noboru. Short-Term Effect of Pitavastatin Treatment on Glucose and Lipid Metabolism and Oxidative Stress in Fasting and Postprandial State Using a Test Meal in Japanese Men. Cholesterol. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-462698
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462698