![](/images/graphics-bg.png)
Serum Galactose-Deficient IgA1 Level Is Not Associated with Proteinuria in Children with IgA Nephropathy
المؤلفون المشاركون
Sanders, John T.
Kane, Oulimata
Novak, Jan
Julian, Bruce A.
Eison, T. Matthew
Moldoveanu, Zina
Wyatt, Robert J.
Hastings, M. Colleen
Lau, Keith K.
Afshan, Sabahat
المصدر
International Journal of Nephrology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-17
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Introduction.
Percentage of galactose-deficient IgA1 (Gd-IgA1) relative to total IgA in serum was recently reported to correlate with proteinuria at time of sampling and during follow-up for pediatric and adult patients with IgA nephropathy.
We sought to determine whether this association exists in another cohort of pediatric patients with IgA nephropathy.
Methods.
Subjects were younger than 18 years at entry.
Blood samples were collected on one or more occasions for determination of serum total IgA and Gd-IgA1.
Gd-IgA1 was expressed as serum level and percent of total IgA.
Urinary protein/creatinine ratio was calculated for random specimens.
Spearman’s correlation coefficients assessed the relationship between study variables.
Results.
The cohort had 29 Caucasians and 11 African-Americans with a male : female ratio of 1.9 : 1.
Mean age at diagnosis was 11.7 ± 3.7 years.
No statistically significant correlation was identified between serum total IgA, Gd-IgA1, or percent Gd-IgA1 versus urinary protein/creatinine ratio determined contemporaneously with biopsy or between average serum Gd-IgA1 or average percent Gd-IgA1 and time-average urinary protein/creatinine ratio.
Conclusion.
The magnitude of proteinuria in this cohort of pediatric patients with IgA nephropathy was influenced by factors other than Gd-IgA1 level, consistent with the proposed multi-hit pathogenetic pathways for this renal disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hastings, M. Colleen& Afshan, Sabahat& Sanders, John T.& Kane, Oulimata& Eison, T. Matthew& Lau, Keith K.…[et al.]. 2012. Serum Galactose-Deficient IgA1 Level Is Not Associated with Proteinuria in Children with IgA Nephropathy. International Journal of Nephrology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-462814
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hastings, M. Colleen…[et al.]. Serum Galactose-Deficient IgA1 Level Is Not Associated with Proteinuria in Children with IgA Nephropathy. International Journal of Nephrology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-462814
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hastings, M. Colleen& Afshan, Sabahat& Sanders, John T.& Kane, Oulimata& Eison, T. Matthew& Lau, Keith K.…[et al.]. Serum Galactose-Deficient IgA1 Level Is Not Associated with Proteinuria in Children with IgA Nephropathy. International Journal of Nephrology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-462814
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-462814
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)