Serum Galactose-Deficient IgA1 Level Is Not Associated with Proteinuria in Children with IgA Nephropathy
Joint Authors
Sanders, John T.
Kane, Oulimata
Novak, Jan
Julian, Bruce A.
Eison, T. Matthew
Moldoveanu, Zina
Wyatt, Robert J.
Hastings, M. Colleen
Lau, Keith K.
Afshan, Sabahat
Source
International Journal of Nephrology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Introduction.
Percentage of galactose-deficient IgA1 (Gd-IgA1) relative to total IgA in serum was recently reported to correlate with proteinuria at time of sampling and during follow-up for pediatric and adult patients with IgA nephropathy.
We sought to determine whether this association exists in another cohort of pediatric patients with IgA nephropathy.
Methods.
Subjects were younger than 18 years at entry.
Blood samples were collected on one or more occasions for determination of serum total IgA and Gd-IgA1.
Gd-IgA1 was expressed as serum level and percent of total IgA.
Urinary protein/creatinine ratio was calculated for random specimens.
Spearman’s correlation coefficients assessed the relationship between study variables.
Results.
The cohort had 29 Caucasians and 11 African-Americans with a male : female ratio of 1.9 : 1.
Mean age at diagnosis was 11.7 ± 3.7 years.
No statistically significant correlation was identified between serum total IgA, Gd-IgA1, or percent Gd-IgA1 versus urinary protein/creatinine ratio determined contemporaneously with biopsy or between average serum Gd-IgA1 or average percent Gd-IgA1 and time-average urinary protein/creatinine ratio.
Conclusion.
The magnitude of proteinuria in this cohort of pediatric patients with IgA nephropathy was influenced by factors other than Gd-IgA1 level, consistent with the proposed multi-hit pathogenetic pathways for this renal disease.
American Psychological Association (APA)
Hastings, M. Colleen& Afshan, Sabahat& Sanders, John T.& Kane, Oulimata& Eison, T. Matthew& Lau, Keith K.…[et al.]. 2012. Serum Galactose-Deficient IgA1 Level Is Not Associated with Proteinuria in Children with IgA Nephropathy. International Journal of Nephrology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-462814
Modern Language Association (MLA)
Hastings, M. Colleen…[et al.]. Serum Galactose-Deficient IgA1 Level Is Not Associated with Proteinuria in Children with IgA Nephropathy. International Journal of Nephrology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-462814
American Medical Association (AMA)
Hastings, M. Colleen& Afshan, Sabahat& Sanders, John T.& Kane, Oulimata& Eison, T. Matthew& Lau, Keith K.…[et al.]. Serum Galactose-Deficient IgA1 Level Is Not Associated with Proteinuria in Children with IgA Nephropathy. International Journal of Nephrology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-462814
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462814