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Age-Related Deficits in Spatial Memory and Hippocampal Spines in Virgin, Female Fischer 344 Rats
المؤلفون المشاركون
Luine, Victoria N.
Frankfurt, Maya
Wallace, Maureen E.
المصدر
Current Gerontology and Geriatrics Research
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-08-18
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Effects of aging on memory and brain morphology were examined in aged, 21-month-old, and young, 4-month-old, Fischer 344 female rats.
Spatial memory was assessed using the object placement task, and dendritic spine density was determined on pyramidal neurons in the hippocampus following Golgi impregnation.
Consistent with previous studies, aged females showed poorer object placement performance than young subjects.
Young subjects significantly discriminated the location of objects with a 1.5-hour intertrial delay while aged subjects did not.
Spine density of basal dendrites on CA1 pyramidal cells was 16% lower in the aged subjects as compared to the young subjects.
No differences in spine density were found between young and aged subjects in basal dendrites of CA1 or in either dendritic field of CA3 pyramidal neurons.
Thus, decreased hippocampal CA1 dendritic spine density in aged rats may contribute to poorer spatial memory as compared to young rats.
The possibility that the neuroplastic changes observed in this study may pertain only to female subjects having had a specific set of life experiences is discussed.
Different factors, such as reproductive status, diet, and handling may contribute to neuroplasticity of the brain during aging; however, this view requires further examination.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Luine, Victoria N.& Wallace, Maureen E.& Frankfurt, Maya. 2011. Age-Related Deficits in Spatial Memory and Hippocampal Spines in Virgin, Female Fischer 344 Rats. Current Gerontology and Geriatrics Research،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-462908
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Luine, Victoria N.…[et al.]. Age-Related Deficits in Spatial Memory and Hippocampal Spines in Virgin, Female Fischer 344 Rats. Current Gerontology and Geriatrics Research No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-462908
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Luine, Victoria N.& Wallace, Maureen E.& Frankfurt, Maya. Age-Related Deficits in Spatial Memory and Hippocampal Spines in Virgin, Female Fischer 344 Rats. Current Gerontology and Geriatrics Research. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-462908
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-462908
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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