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Age-Related Deficits in Spatial Memory and Hippocampal Spines in Virgin, Female Fischer 344 Rats
Joint Authors
Luine, Victoria N.
Frankfurt, Maya
Wallace, Maureen E.
Source
Current Gerontology and Geriatrics Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Effects of aging on memory and brain morphology were examined in aged, 21-month-old, and young, 4-month-old, Fischer 344 female rats.
Spatial memory was assessed using the object placement task, and dendritic spine density was determined on pyramidal neurons in the hippocampus following Golgi impregnation.
Consistent with previous studies, aged females showed poorer object placement performance than young subjects.
Young subjects significantly discriminated the location of objects with a 1.5-hour intertrial delay while aged subjects did not.
Spine density of basal dendrites on CA1 pyramidal cells was 16% lower in the aged subjects as compared to the young subjects.
No differences in spine density were found between young and aged subjects in basal dendrites of CA1 or in either dendritic field of CA3 pyramidal neurons.
Thus, decreased hippocampal CA1 dendritic spine density in aged rats may contribute to poorer spatial memory as compared to young rats.
The possibility that the neuroplastic changes observed in this study may pertain only to female subjects having had a specific set of life experiences is discussed.
Different factors, such as reproductive status, diet, and handling may contribute to neuroplasticity of the brain during aging; however, this view requires further examination.
American Psychological Association (APA)
Luine, Victoria N.& Wallace, Maureen E.& Frankfurt, Maya. 2011. Age-Related Deficits in Spatial Memory and Hippocampal Spines in Virgin, Female Fischer 344 Rats. Current Gerontology and Geriatrics Research،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-462908
Modern Language Association (MLA)
Luine, Victoria N.…[et al.]. Age-Related Deficits in Spatial Memory and Hippocampal Spines in Virgin, Female Fischer 344 Rats. Current Gerontology and Geriatrics Research No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-462908
American Medical Association (AMA)
Luine, Victoria N.& Wallace, Maureen E.& Frankfurt, Maya. Age-Related Deficits in Spatial Memory and Hippocampal Spines in Virgin, Female Fischer 344 Rats. Current Gerontology and Geriatrics Research. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-462908
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462908