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Effects of a Pseudophysiological Environment on the Elastic and Viscoelastic Properties of Collagen Gels
المؤلفون المشاركون
Meghezi, Sébastien
Chevallier, Pascale
Couet, Frédéric
Mantovani, Diego
المصدر
International Journal of Biomaterials
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-07-12
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Vascular tissue engineering focuses on the replacement of diseased small-diameter blood vessels with a diameter less than 6 mm for which adequate substitutes still do not exist.
One approach to vascular tissue engineering is to culture vascular cells on a scaffold in a bioreactor.
The bioreactor establishes pseudophysiological conditions for culture (medium culture, 37°C, mechanical stimulation).
Collagen gels are widely used as scaffolds for tissue regeneration due to their biological properties; however, they exhibit low mechanical properties.
Mechanical characterization of these scaffolds requires establishing the conditions of testing in regard to the conditions set in the bioreactor.
The effects of different parameters used during mechanical testing on the collagen gels were evaluated in terms of mechanical and viscoelastic properties.
Thus, a factorial experiment was adopted, and three relevant factors were considered: temperature (23°C or 37°C), hydration (aqueous saline solution or air), and mechanical preconditioning (with or without).
Statistical analyses showed significant effects of these factors on the mechanical properties which were assessed by tensile tests as well as stress relaxation tests.
The last tests provide a more consistent understanding of the gels' viscoelastic properties.
Therefore, performing mechanical analyses on hydrogels requires setting an adequate environment in terms of temperature and aqueous saline solution as well as choosing the adequate test.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Meghezi, Sébastien& Couet, Frédéric& Chevallier, Pascale& Mantovani, Diego. 2012. Effects of a Pseudophysiological Environment on the Elastic and Viscoelastic Properties of Collagen Gels. International Journal of Biomaterials،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-463172
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Meghezi, Sébastien…[et al.]. Effects of a Pseudophysiological Environment on the Elastic and Viscoelastic Properties of Collagen Gels. International Journal of Biomaterials No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-463172
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Meghezi, Sébastien& Couet, Frédéric& Chevallier, Pascale& Mantovani, Diego. Effects of a Pseudophysiological Environment on the Elastic and Viscoelastic Properties of Collagen Gels. International Journal of Biomaterials. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-463172
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-463172
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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