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Effects of a Pseudophysiological Environment on the Elastic and Viscoelastic Properties of Collagen Gels
Joint Authors
Meghezi, Sébastien
Chevallier, Pascale
Couet, Frédéric
Mantovani, Diego
Source
International Journal of Biomaterials
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Vascular tissue engineering focuses on the replacement of diseased small-diameter blood vessels with a diameter less than 6 mm for which adequate substitutes still do not exist.
One approach to vascular tissue engineering is to culture vascular cells on a scaffold in a bioreactor.
The bioreactor establishes pseudophysiological conditions for culture (medium culture, 37°C, mechanical stimulation).
Collagen gels are widely used as scaffolds for tissue regeneration due to their biological properties; however, they exhibit low mechanical properties.
Mechanical characterization of these scaffolds requires establishing the conditions of testing in regard to the conditions set in the bioreactor.
The effects of different parameters used during mechanical testing on the collagen gels were evaluated in terms of mechanical and viscoelastic properties.
Thus, a factorial experiment was adopted, and three relevant factors were considered: temperature (23°C or 37°C), hydration (aqueous saline solution or air), and mechanical preconditioning (with or without).
Statistical analyses showed significant effects of these factors on the mechanical properties which were assessed by tensile tests as well as stress relaxation tests.
The last tests provide a more consistent understanding of the gels' viscoelastic properties.
Therefore, performing mechanical analyses on hydrogels requires setting an adequate environment in terms of temperature and aqueous saline solution as well as choosing the adequate test.
American Psychological Association (APA)
Meghezi, Sébastien& Couet, Frédéric& Chevallier, Pascale& Mantovani, Diego. 2012. Effects of a Pseudophysiological Environment on the Elastic and Viscoelastic Properties of Collagen Gels. International Journal of Biomaterials،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-463172
Modern Language Association (MLA)
Meghezi, Sébastien…[et al.]. Effects of a Pseudophysiological Environment on the Elastic and Viscoelastic Properties of Collagen Gels. International Journal of Biomaterials No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-463172
American Medical Association (AMA)
Meghezi, Sébastien& Couet, Frédéric& Chevallier, Pascale& Mantovani, Diego. Effects of a Pseudophysiological Environment on the Elastic and Viscoelastic Properties of Collagen Gels. International Journal of Biomaterials. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-463172
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463172