Sildenafil (Viagra) Protective Effects on Neuroinflammation : The Role of iNOSNO System in an Inflammatory Demyelination Model
المؤلفون المشاركون
Raposo, Catarina
Luna, Rayana Leal de Almeida
Peixoto, Christina Alves
da Cruz-Höfling, Maria Alice
Araújo, Shyrlene Meiry da Rocha
Nunes, Ana Karolina de Santana
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-22
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
We recently demonstrated that sildenafil reduces the expression of cytokines, COX-2, and GFAP in a demyelinating model induced in wild-type (WT) mice.
Herein, the understandings of the neuroprotective effect of sildenafil and the mediation of iNOS/NO system on inflammatory demyelination induced by cuprizone were investigated.
The cerebella of iNOS−/− mice were examined after four weeks of treatment with cuprizone alone or combined with sildenafil.
Cuprizone increased GFAP, Iba-1, TNF-α, COX-2, IL-1β, and IFN-γ expression, decreased expression of glutathione S-transferase pi (GSTpi), and damaged myelin in iNOS−/− mice.
Sildenafil reduced Iba-1, IFN-γ, and IL-1β levels but had no effect on the expression of GFAP, TNF-α, and COX-2 compared to the cuprizone group.
Sildenafil elevated GSTpi levels and improved the myelin structure/ultrastructure.
iNOS−/− mice suffered from severe inflammation following treatment with cuprizone, while WT mice had milder inflammation, as found in the previous study.
It is possible that inflammatory regulation through iNOS-feedback is absent in iNOS−/− mice, making them more susceptible to inflammation.
Sildenafil has at least a partial anti-inflammatory effect through iNOS inhibition, as its effect on iNOS−/− mice was limited.
Further studies are required to explain the underlying mechanism of the sildenafil effects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Raposo, Catarina& Nunes, Ana Karolina de Santana& Luna, Rayana Leal de Almeida& Araújo, Shyrlene Meiry da Rocha& da Cruz-Höfling, Maria Alice& Peixoto, Christina Alves. 2013. Sildenafil (Viagra) Protective Effects on Neuroinflammation : The Role of iNOSNO System in an Inflammatory Demyelination Model. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-463365
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Raposo, Catarina…[et al.]. Sildenafil (Viagra) Protective Effects on Neuroinflammation : The Role of iNOSNO System in an Inflammatory Demyelination Model. Mediators of Inflammation No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-463365
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Raposo, Catarina& Nunes, Ana Karolina de Santana& Luna, Rayana Leal de Almeida& Araújo, Shyrlene Meiry da Rocha& da Cruz-Höfling, Maria Alice& Peixoto, Christina Alves. Sildenafil (Viagra) Protective Effects on Neuroinflammation : The Role of iNOSNO System in an Inflammatory Demyelination Model. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-463365
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-463365
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر