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A Novel Role for Raloxifene Nanomicelles in Management of Castrate Resistant Prostate Cancer
المؤلفون المشاركون
Nehoff, Hayley
Greish, Khaled
Rosengren, Rhonda J.
Taurin, Sebastien
van Aswegen, Thalita
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-06
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Of patients with castrate resistant prostate cancer (CRPC), less than 25–33% survive more than five years.
Recent studies have implicated estrogen, acting either alone or synergistically with androgens in the development of castrate resistant prostate cancer.
Several in vitro and in vivo studies, as well as a limited number of clinical trials, have highlighted the potential of selective estrogen receptor modulators, such as raloxifene (Ral) for the treatment of castrate resistant prostate cancer.
However, the poor oral bioavailability and metabolism of selective estrogen receptor modulators limit their efficiency in clinical application.
To overcome these limitations, we have used styrene co-maleic acid (SMA) micelle to encapsulate raloxifene.
Compared to free drug, SMA-Ral micelles had 132 and 140% higher cytotoxicity against PC3 and DU 145 prostate cell lines, respectively.
SMA-Ral effectively inhibits cell cycle progression, increases apoptosis, and alters the integrity of tumor spheroid models.
In addition, the micellar system induced changes in expression and localization of estrogen receptors, epidermal growth factor receptor (EGFR), and downstream effectors associated with cell proliferation and survival.
Finally, SMA-Ral treatment decreased migration and invasion of castrate resistant prostate cancer cell lines.
In conclusion, SMA-Ral micelles can potentially benefit new strategies for clinical management of castrate resistant prostate cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Taurin, Sebastien& Nehoff, Hayley& van Aswegen, Thalita& Rosengren, Rhonda J.& Greish, Khaled. 2014. A Novel Role for Raloxifene Nanomicelles in Management of Castrate Resistant Prostate Cancer. BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-463456
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Taurin, Sebastien…[et al.]. A Novel Role for Raloxifene Nanomicelles in Management of Castrate Resistant Prostate Cancer. BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-463456
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Taurin, Sebastien& Nehoff, Hayley& van Aswegen, Thalita& Rosengren, Rhonda J.& Greish, Khaled. A Novel Role for Raloxifene Nanomicelles in Management of Castrate Resistant Prostate Cancer. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-463456
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-463456
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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