![](/images/graphics-bg.png)
A Novel Role for Raloxifene Nanomicelles in Management of Castrate Resistant Prostate Cancer
Joint Authors
Nehoff, Hayley
Greish, Khaled
Rosengren, Rhonda J.
Taurin, Sebastien
van Aswegen, Thalita
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-06
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Of patients with castrate resistant prostate cancer (CRPC), less than 25–33% survive more than five years.
Recent studies have implicated estrogen, acting either alone or synergistically with androgens in the development of castrate resistant prostate cancer.
Several in vitro and in vivo studies, as well as a limited number of clinical trials, have highlighted the potential of selective estrogen receptor modulators, such as raloxifene (Ral) for the treatment of castrate resistant prostate cancer.
However, the poor oral bioavailability and metabolism of selective estrogen receptor modulators limit their efficiency in clinical application.
To overcome these limitations, we have used styrene co-maleic acid (SMA) micelle to encapsulate raloxifene.
Compared to free drug, SMA-Ral micelles had 132 and 140% higher cytotoxicity against PC3 and DU 145 prostate cell lines, respectively.
SMA-Ral effectively inhibits cell cycle progression, increases apoptosis, and alters the integrity of tumor spheroid models.
In addition, the micellar system induced changes in expression and localization of estrogen receptors, epidermal growth factor receptor (EGFR), and downstream effectors associated with cell proliferation and survival.
Finally, SMA-Ral treatment decreased migration and invasion of castrate resistant prostate cancer cell lines.
In conclusion, SMA-Ral micelles can potentially benefit new strategies for clinical management of castrate resistant prostate cancer.
American Psychological Association (APA)
Taurin, Sebastien& Nehoff, Hayley& van Aswegen, Thalita& Rosengren, Rhonda J.& Greish, Khaled. 2014. A Novel Role for Raloxifene Nanomicelles in Management of Castrate Resistant Prostate Cancer. BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-463456
Modern Language Association (MLA)
Taurin, Sebastien…[et al.]. A Novel Role for Raloxifene Nanomicelles in Management of Castrate Resistant Prostate Cancer. BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-463456
American Medical Association (AMA)
Taurin, Sebastien& Nehoff, Hayley& van Aswegen, Thalita& Rosengren, Rhonda J.& Greish, Khaled. A Novel Role for Raloxifene Nanomicelles in Management of Castrate Resistant Prostate Cancer. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-463456
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463456