![](/images/graphics-bg.png)
Therapeutic Approach to Neurodegenerative Diseases by Medical Gases : Focusing on Redox Signaling and Related Antioxidant Enzymes
المؤلفون المشاركون
Fujita, Kyota
Nakabeppu, Yusaku
Yamafuji, Megumi
Noda, Mami
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-07-01
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
Oxidative stress in the central nervous system is strongly associated with neuronal cell death in the pathogenesis of several neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis.
In order to overcome the oxidative damage, there are some protective signaling pathways related to transcriptional upregulation of antioxidant enzymes, such as heme oxygenase-1 (HO-1) and superoxide dismutase (SOD)-1/-2.
Their expression is regulated by several transcription factors and/or cofactors like nuclear factor-erythroid 2 (NF-E2) related factor 2 (Nrf2) and peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α).
These antioxidant enzymes are associated with, and in some cases, prevent neuronal death in animal models of neurodegenerative diseases.
They are activated by endogenous mediators and phytochemicals, and also by several gases such as carbon monoxide (CO), hydrogen sulphide (H2S), and hydrogen (H2).
These might thereby protect the brain from severe oxidative damage and resultant neurodegenerative diseases.
In this paper, we discuss how the expression levels of these antioxidant enzymes are regulated.
We also introduce recent advances in the therapeutic uses of medical gases against neurodegenerative diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fujita, Kyota& Yamafuji, Megumi& Nakabeppu, Yusaku& Noda, Mami. 2012. Therapeutic Approach to Neurodegenerative Diseases by Medical Gases : Focusing on Redox Signaling and Related Antioxidant Enzymes. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-463514
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fujita, Kyota…[et al.]. Therapeutic Approach to Neurodegenerative Diseases by Medical Gases : Focusing on Redox Signaling and Related Antioxidant Enzymes. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-463514
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fujita, Kyota& Yamafuji, Megumi& Nakabeppu, Yusaku& Noda, Mami. Therapeutic Approach to Neurodegenerative Diseases by Medical Gases : Focusing on Redox Signaling and Related Antioxidant Enzymes. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-463514
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-463514
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)