Therapeutic Approach to Neurodegenerative Diseases by Medical Gases : Focusing on Redox Signaling and Related Antioxidant Enzymes
Joint Authors
Fujita, Kyota
Nakabeppu, Yusaku
Yamafuji, Megumi
Noda, Mami
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Oxidative stress in the central nervous system is strongly associated with neuronal cell death in the pathogenesis of several neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis.
In order to overcome the oxidative damage, there are some protective signaling pathways related to transcriptional upregulation of antioxidant enzymes, such as heme oxygenase-1 (HO-1) and superoxide dismutase (SOD)-1/-2.
Their expression is regulated by several transcription factors and/or cofactors like nuclear factor-erythroid 2 (NF-E2) related factor 2 (Nrf2) and peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α).
These antioxidant enzymes are associated with, and in some cases, prevent neuronal death in animal models of neurodegenerative diseases.
They are activated by endogenous mediators and phytochemicals, and also by several gases such as carbon monoxide (CO), hydrogen sulphide (H2S), and hydrogen (H2).
These might thereby protect the brain from severe oxidative damage and resultant neurodegenerative diseases.
In this paper, we discuss how the expression levels of these antioxidant enzymes are regulated.
We also introduce recent advances in the therapeutic uses of medical gases against neurodegenerative diseases.
American Psychological Association (APA)
Fujita, Kyota& Yamafuji, Megumi& Nakabeppu, Yusaku& Noda, Mami. 2012. Therapeutic Approach to Neurodegenerative Diseases by Medical Gases : Focusing on Redox Signaling and Related Antioxidant Enzymes. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-463514
Modern Language Association (MLA)
Fujita, Kyota…[et al.]. Therapeutic Approach to Neurodegenerative Diseases by Medical Gases : Focusing on Redox Signaling and Related Antioxidant Enzymes. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-463514
American Medical Association (AMA)
Fujita, Kyota& Yamafuji, Megumi& Nakabeppu, Yusaku& Noda, Mami. Therapeutic Approach to Neurodegenerative Diseases by Medical Gases : Focusing on Redox Signaling and Related Antioxidant Enzymes. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-463514
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463514