The GRK2 Overexpression Is a Primary Hallmark of Mitochondrial Lesions during Early Alzheimer Disease
المؤلفون المشاركون
Aliev, Gjumrakch
Gasimov, Eldar
Palacios, Hector H.
Leszek, Jerzy
Obrenovich, Mark E.
المصدر
Cardiovascular Psychiatry and Neurology
العدد
المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-03-03
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Increasing evidence points to vascular damage as an early contributor to the development of two leading causes of age-associated dementia, namely Alzheimer disease (AD) and AD-like pathology such as stroke.
This review focuses on the role of G protein-coupled receptor kinases (GRKs) as they relate to dementia and how the cardio and cerebrovasculature is involved in AD pathogenesis.
The exploration of GRKs in AD pathogenesis may help bridge gaps in our understanding of the heart-brain connection in relation to neurovisceral damage and vascular complications of AD.
The a priori basis for this inquiry stems from the fact that kinases of this family regulate numerous receptor functions in the brain, myocardium and elsewhere.
The aim of this review is to discuss the finding of GRK2 overexpression in the context of early AD pathogenesis.
Also, we consider the consequences for this overexpression as a loss of G-protein coupled receptor (GPCR) regulation, as well as suggest a potential role for GPCRs and GRKs in a unifying theory of AD pathogenesis through the cerebrovasculature.
Finally, we synthesize this newer information in an attempt to put it into context with GRKs as regulators of cellular function, which makes these proteins potential diagnostic and therapeutic targets for future pharmacological intervention.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Obrenovich, Mark E.& Palacios, Hector H.& Gasimov, Eldar& Leszek, Jerzy& Aliev, Gjumrakch. 2010. The GRK2 Overexpression Is a Primary Hallmark of Mitochondrial Lesions during Early Alzheimer Disease. Cardiovascular Psychiatry and Neurology،Vol. 2009, no. 2009, pp.1-14.
https://search.emarefa.net/detail/BIM-463832
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Obrenovich, Mark E.…[et al.]. The GRK2 Overexpression Is a Primary Hallmark of Mitochondrial Lesions during Early Alzheimer Disease. Cardiovascular Psychiatry and Neurology No. 2009 (2009), pp.1-14.
https://search.emarefa.net/detail/BIM-463832
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Obrenovich, Mark E.& Palacios, Hector H.& Gasimov, Eldar& Leszek, Jerzy& Aliev, Gjumrakch. The GRK2 Overexpression Is a Primary Hallmark of Mitochondrial Lesions during Early Alzheimer Disease. Cardiovascular Psychiatry and Neurology. 2010. Vol. 2009, no. 2009, pp.1-14.
https://search.emarefa.net/detail/BIM-463832
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-463832
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر