The GRK2 Overexpression Is a Primary Hallmark of Mitochondrial Lesions during Early Alzheimer Disease
Joint Authors
Aliev, Gjumrakch
Gasimov, Eldar
Palacios, Hector H.
Leszek, Jerzy
Obrenovich, Mark E.
Source
Cardiovascular Psychiatry and Neurology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-03
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Increasing evidence points to vascular damage as an early contributor to the development of two leading causes of age-associated dementia, namely Alzheimer disease (AD) and AD-like pathology such as stroke.
This review focuses on the role of G protein-coupled receptor kinases (GRKs) as they relate to dementia and how the cardio and cerebrovasculature is involved in AD pathogenesis.
The exploration of GRKs in AD pathogenesis may help bridge gaps in our understanding of the heart-brain connection in relation to neurovisceral damage and vascular complications of AD.
The a priori basis for this inquiry stems from the fact that kinases of this family regulate numerous receptor functions in the brain, myocardium and elsewhere.
The aim of this review is to discuss the finding of GRK2 overexpression in the context of early AD pathogenesis.
Also, we consider the consequences for this overexpression as a loss of G-protein coupled receptor (GPCR) regulation, as well as suggest a potential role for GPCRs and GRKs in a unifying theory of AD pathogenesis through the cerebrovasculature.
Finally, we synthesize this newer information in an attempt to put it into context with GRKs as regulators of cellular function, which makes these proteins potential diagnostic and therapeutic targets for future pharmacological intervention.
American Psychological Association (APA)
Obrenovich, Mark E.& Palacios, Hector H.& Gasimov, Eldar& Leszek, Jerzy& Aliev, Gjumrakch. 2010. The GRK2 Overexpression Is a Primary Hallmark of Mitochondrial Lesions during Early Alzheimer Disease. Cardiovascular Psychiatry and Neurology،Vol. 2009, no. 2009, pp.1-14.
https://search.emarefa.net/detail/BIM-463832
Modern Language Association (MLA)
Obrenovich, Mark E.…[et al.]. The GRK2 Overexpression Is a Primary Hallmark of Mitochondrial Lesions during Early Alzheimer Disease. Cardiovascular Psychiatry and Neurology No. 2009 (2009), pp.1-14.
https://search.emarefa.net/detail/BIM-463832
American Medical Association (AMA)
Obrenovich, Mark E.& Palacios, Hector H.& Gasimov, Eldar& Leszek, Jerzy& Aliev, Gjumrakch. The GRK2 Overexpression Is a Primary Hallmark of Mitochondrial Lesions during Early Alzheimer Disease. Cardiovascular Psychiatry and Neurology. 2010. Vol. 2009, no. 2009, pp.1-14.
https://search.emarefa.net/detail/BIM-463832
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463832