Polymerized-Type I Collagen Downregulates Inflammation and Improves Clinical Outcomes in Patients with Symptomatic Knee Osteoarthritis Following Arthroscopic Lavage : A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial
المؤلفون المشاركون
Llorente, Luis
Lima, Guadalupe
Hernández-Cuevas, Virgilio
Echevarría-Zuno, Santiago
Ruiz-Ordaz, Blanca H.
Nuñez-Álvarez, Carlos
Furuzawa-Carballeda, Janette
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-04-01
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
Objectives.
Polymerized-type I collagen (polymerized collagen) is a downmodulator of inflammation and cartilage regenerator biodrug.
Aim.
To evaluate the effect of intraarticular injections of polymerized collagen after arthroscopic lavage on inflammation and clinical improvement in patients with knee osteoarthritis (OA).
Methods.
Patients (n=19) were treated with 6 intraarticular injections of 2 mL of polymerized collagen (n=10) or 2 mL of placebo (n=9) during 3 months.
Followup was 3 months.
The primary endpoints included Lequesne index, pain on a visual analogue scale (VAS), WOMAC, analgesic usage, the number of Tregs and proinflammatory/anti-inflammatory cytokine-expressing peripheral cells.
Secondary outcomes were Likert score and drug evaluation.
Clinical and immunological improvement was determined if the decrease in pain exceeds 20 mm on a VAS, 20% of clinical outcomes, and inflammatory parameters from baseline.
Urinary levels of C-terminal crosslinking telopeptide of collagen type II (CTXII) and erythrocyte sedimentation rate (ESR) were determined.
Results.
Polymerized collagen was safe and well tolerated.
Patients had a statistically significant improvement (P<0.05) from baseline versus polymerized collagen and versus placebo at 6 months on Lequesne index, VAS, ESR, Tregs IL-1β, and IL-10 peripheral-expressing cells.
Urinary levels of CTXII were decreased 44% in polymerized collagen versus placebo.
No differences were found on incidence of adverse events between groups.
Conclusion.
Polymerized collagen is safe and effective on downregulation of inflammation in patients with knee OA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Furuzawa-Carballeda, Janette& Lima, Guadalupe& Llorente, Luis& Nuñez-Álvarez, Carlos& Ruiz-Ordaz, Blanca H.& Echevarría-Zuno, Santiago…[et al.]. 2012. Polymerized-Type I Collagen Downregulates Inflammation and Improves Clinical Outcomes in Patients with Symptomatic Knee Osteoarthritis Following Arthroscopic Lavage : A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-464360
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Furuzawa-Carballeda, Janette…[et al.]. Polymerized-Type I Collagen Downregulates Inflammation and Improves Clinical Outcomes in Patients with Symptomatic Knee Osteoarthritis Following Arthroscopic Lavage : A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial. The Scientific World Journal No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-464360
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Furuzawa-Carballeda, Janette& Lima, Guadalupe& Llorente, Luis& Nuñez-Álvarez, Carlos& Ruiz-Ordaz, Blanca H.& Echevarría-Zuno, Santiago…[et al.]. Polymerized-Type I Collagen Downregulates Inflammation and Improves Clinical Outcomes in Patients with Symptomatic Knee Osteoarthritis Following Arthroscopic Lavage : A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-464360
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-464360
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر