Polymerized-Type I Collagen Downregulates Inflammation and Improves Clinical Outcomes in Patients with Symptomatic Knee Osteoarthritis Following Arthroscopic Lavage : A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial
Joint Authors
Llorente, Luis
Lima, Guadalupe
Hernández-Cuevas, Virgilio
Echevarría-Zuno, Santiago
Ruiz-Ordaz, Blanca H.
Nuñez-Álvarez, Carlos
Furuzawa-Carballeda, Janette
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Objectives.
Polymerized-type I collagen (polymerized collagen) is a downmodulator of inflammation and cartilage regenerator biodrug.
Aim.
To evaluate the effect of intraarticular injections of polymerized collagen after arthroscopic lavage on inflammation and clinical improvement in patients with knee osteoarthritis (OA).
Methods.
Patients (n=19) were treated with 6 intraarticular injections of 2 mL of polymerized collagen (n=10) or 2 mL of placebo (n=9) during 3 months.
Followup was 3 months.
The primary endpoints included Lequesne index, pain on a visual analogue scale (VAS), WOMAC, analgesic usage, the number of Tregs and proinflammatory/anti-inflammatory cytokine-expressing peripheral cells.
Secondary outcomes were Likert score and drug evaluation.
Clinical and immunological improvement was determined if the decrease in pain exceeds 20 mm on a VAS, 20% of clinical outcomes, and inflammatory parameters from baseline.
Urinary levels of C-terminal crosslinking telopeptide of collagen type II (CTXII) and erythrocyte sedimentation rate (ESR) were determined.
Results.
Polymerized collagen was safe and well tolerated.
Patients had a statistically significant improvement (P<0.05) from baseline versus polymerized collagen and versus placebo at 6 months on Lequesne index, VAS, ESR, Tregs IL-1β, and IL-10 peripheral-expressing cells.
Urinary levels of CTXII were decreased 44% in polymerized collagen versus placebo.
No differences were found on incidence of adverse events between groups.
Conclusion.
Polymerized collagen is safe and effective on downregulation of inflammation in patients with knee OA.
American Psychological Association (APA)
Furuzawa-Carballeda, Janette& Lima, Guadalupe& Llorente, Luis& Nuñez-Álvarez, Carlos& Ruiz-Ordaz, Blanca H.& Echevarría-Zuno, Santiago…[et al.]. 2012. Polymerized-Type I Collagen Downregulates Inflammation and Improves Clinical Outcomes in Patients with Symptomatic Knee Osteoarthritis Following Arthroscopic Lavage : A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-464360
Modern Language Association (MLA)
Furuzawa-Carballeda, Janette…[et al.]. Polymerized-Type I Collagen Downregulates Inflammation and Improves Clinical Outcomes in Patients with Symptomatic Knee Osteoarthritis Following Arthroscopic Lavage : A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial. The Scientific World Journal No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-464360
American Medical Association (AMA)
Furuzawa-Carballeda, Janette& Lima, Guadalupe& Llorente, Luis& Nuñez-Álvarez, Carlos& Ruiz-Ordaz, Blanca H.& Echevarría-Zuno, Santiago…[et al.]. Polymerized-Type I Collagen Downregulates Inflammation and Improves Clinical Outcomes in Patients with Symptomatic Knee Osteoarthritis Following Arthroscopic Lavage : A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-464360
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464360