(E)‎3-2-(1-(2,4-Dihydroxyphenyl)‎ethyldeneamino)‎phenyl)‎-2-methylquinazoline-4(3H)‎-one Schiff Base and Its Metal Complexes : A New Drug of Choice against Methicillin-Resistant Staphylococcus aureus

الملخص EN

The 3-(2-aminophenyl) quinazolin-2-methyl-4(3H)-one and 2,4-dihydroxyacetophenone undergo condensation to afford (E)3-2-(1-(2,4-dihydroxyphenyl)ethyldeneamino)phenyl)-2-methylquinazoline-4(3H)-one Schiff base (DHPEAPMQ).

The newly synthesized Schiff base (DHPEAPMQ) and its metal complexes were evaluated for their antimicrobial activity against methicillin-resistant Staphylococcus aureus isolated from the Gulbarga region in India.

The Cu(II), Ni(II), and Zn(II) complexes of Schiff base (DHPEAPMQ) showed good antimicrobial activity.

So, this could be a new drug of choice.