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Evaluation of Clinical and Immunological Responses : A 2-Year Follow-Up Study in Children with Allergic Rhinitis due to House Dust Mite
المؤلفون المشاركون
Gerth van Wijk, Roy
Hendriks, Rudi W.
Moed, Heleen
van der Wouden, J. C.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-04-27
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Allergic rhinitis is a disease with polarization towards Th2 and a defect of regulatory T cells.
Immunological changes have been reported after immunotherapy treatment.
However, there is not much known about the natural course of allergic rhinitis with respect to clinical manifestation and the relation with immunological responses.
Objective.
To evaluate clinical symptoms of allergic rhinitis, in relation to in vivo allergen-specific skin responses and in vitro allergen-specific effector and regulatory T cells determined at baseline and after two years.
Methods.
From a large trial, 59 children were randomly selected.
The following variables were compared: clinical symptoms, allergen skin tests, specific IgE, T-cell proliferation, IL-5, IL-13, IFN-gamma, IL-10, TGF-beta, CD4+CD25hi cells, and Foxp3 expression.
Results.
Allergic symptoms had decreased after two years.
Whereas skin test reactions correlated between years 0 and 2, there was no change in the size of the reaction.
Also, proinflammatory reactions did not change after two years, with a positive correlation between years 0 and 2.
No relevant changes were observed with respect to regulatory cells.
Conclusion.
Whereas, comparable to immunotherapy, allergic complaints decrease, the immunological changes of specific T-cell activity (both effector cells and regulator cells) which are observed after immunotherapy, do not change.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Moed, Heleen& Gerth van Wijk, Roy& Hendriks, Rudi W.& van der Wouden, J. C.. 2013. Evaluation of Clinical and Immunological Responses : A 2-Year Follow-Up Study in Children with Allergic Rhinitis due to House Dust Mite. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-464460
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Moed, Heleen…[et al.]. Evaluation of Clinical and Immunological Responses : A 2-Year Follow-Up Study in Children with Allergic Rhinitis due to House Dust Mite. Mediators of Inflammation No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-464460
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Moed, Heleen& Gerth van Wijk, Roy& Hendriks, Rudi W.& van der Wouden, J. C.. Evaluation of Clinical and Immunological Responses : A 2-Year Follow-Up Study in Children with Allergic Rhinitis due to House Dust Mite. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-464460
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-464460
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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