Repair of Segmental Load-Bearing Bone Defect by Autologous Mesenchymal Stem Cells and Plasma-Derived Fibrin Impregnated Ceramic Block Results in Early Recovery of Limb Function
المؤلفون المشاركون
Idrus, Ruszymah Bt Hj
Ng, Min Hwei
Duski, Suryasmi
Mohamed, Zahiah
Bin Saim, Aminuddin
Tan, Kok Keong
Mohamed Rose, Isa
Yusof, Mohd Reusmaazran
Low, Kiat Cheong
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-07
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Calcium phosphate-based bone substitutes have not been used to repair load-bearing bone defects due to their weak mechanical property.
In this study, we reevaluated the functional outcomes of combining ceramic block with osteogenic-induced mesenchymal stem cells and platelet-rich plasma (TEB) to repair critical-sized segmental tibial defect.
Comparisons were made with fresh marrow-impregnated ceramic block (MIC) and partially demineralized allogeneic bone block (ALLO).
Six New Zealand White female rabbits were used in each study group and three rabbits with no implants were used as negative controls.
By Day 90, 4/6 rabbits in TEB group and 2/6 in ALLO and MIC groups resumed normal gait pattern.
Union was achieved significantly faster in TEB group with a radiological score of 4.50 ± 0.78 versus ALLO (1.06 ± 0.32), MIC (1.28 ± 0.24), and negative controls (0).
Histologically, TEB group scored the highest percentage of new bone (82% ± 5.1%) compared to ALLO (5% ± 2.5%) and MIC (26% ± 5.2%).
Biomechanically, TEB-treated tibiae achieved the highest compressive strength (43.50 ± 12.72 MPa) compared to those treated with ALLO (15.15 ± 3.57 MPa) and MIC (23.28 ± 6.14 MPa).
In conclusion, TEB can repair critical-sized segmental load-bearing bone defects and restore limb function.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ng, Min Hwei& Duski, Suryasmi& Tan, Kok Keong& Yusof, Mohd Reusmaazran& Low, Kiat Cheong& Mohamed Rose, Isa…[et al.]. 2014. Repair of Segmental Load-Bearing Bone Defect by Autologous Mesenchymal Stem Cells and Plasma-Derived Fibrin Impregnated Ceramic Block Results in Early Recovery of Limb Function. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-464511
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ng, Min Hwei…[et al.]. Repair of Segmental Load-Bearing Bone Defect by Autologous Mesenchymal Stem Cells and Plasma-Derived Fibrin Impregnated Ceramic Block Results in Early Recovery of Limb Function. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-464511
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ng, Min Hwei& Duski, Suryasmi& Tan, Kok Keong& Yusof, Mohd Reusmaazran& Low, Kiat Cheong& Mohamed Rose, Isa…[et al.]. Repair of Segmental Load-Bearing Bone Defect by Autologous Mesenchymal Stem Cells and Plasma-Derived Fibrin Impregnated Ceramic Block Results in Early Recovery of Limb Function. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-464511
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-464511
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر