Repair of Segmental Load-Bearing Bone Defect by Autologous Mesenchymal Stem Cells and Plasma-Derived Fibrin Impregnated Ceramic Block Results in Early Recovery of Limb Function
Joint Authors
Idrus, Ruszymah Bt Hj
Ng, Min Hwei
Duski, Suryasmi
Mohamed, Zahiah
Bin Saim, Aminuddin
Tan, Kok Keong
Mohamed Rose, Isa
Yusof, Mohd Reusmaazran
Low, Kiat Cheong
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-07
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Calcium phosphate-based bone substitutes have not been used to repair load-bearing bone defects due to their weak mechanical property.
In this study, we reevaluated the functional outcomes of combining ceramic block with osteogenic-induced mesenchymal stem cells and platelet-rich plasma (TEB) to repair critical-sized segmental tibial defect.
Comparisons were made with fresh marrow-impregnated ceramic block (MIC) and partially demineralized allogeneic bone block (ALLO).
Six New Zealand White female rabbits were used in each study group and three rabbits with no implants were used as negative controls.
By Day 90, 4/6 rabbits in TEB group and 2/6 in ALLO and MIC groups resumed normal gait pattern.
Union was achieved significantly faster in TEB group with a radiological score of 4.50 ± 0.78 versus ALLO (1.06 ± 0.32), MIC (1.28 ± 0.24), and negative controls (0).
Histologically, TEB group scored the highest percentage of new bone (82% ± 5.1%) compared to ALLO (5% ± 2.5%) and MIC (26% ± 5.2%).
Biomechanically, TEB-treated tibiae achieved the highest compressive strength (43.50 ± 12.72 MPa) compared to those treated with ALLO (15.15 ± 3.57 MPa) and MIC (23.28 ± 6.14 MPa).
In conclusion, TEB can repair critical-sized segmental load-bearing bone defects and restore limb function.
American Psychological Association (APA)
Ng, Min Hwei& Duski, Suryasmi& Tan, Kok Keong& Yusof, Mohd Reusmaazran& Low, Kiat Cheong& Mohamed Rose, Isa…[et al.]. 2014. Repair of Segmental Load-Bearing Bone Defect by Autologous Mesenchymal Stem Cells and Plasma-Derived Fibrin Impregnated Ceramic Block Results in Early Recovery of Limb Function. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-464511
Modern Language Association (MLA)
Ng, Min Hwei…[et al.]. Repair of Segmental Load-Bearing Bone Defect by Autologous Mesenchymal Stem Cells and Plasma-Derived Fibrin Impregnated Ceramic Block Results in Early Recovery of Limb Function. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-464511
American Medical Association (AMA)
Ng, Min Hwei& Duski, Suryasmi& Tan, Kok Keong& Yusof, Mohd Reusmaazran& Low, Kiat Cheong& Mohamed Rose, Isa…[et al.]. Repair of Segmental Load-Bearing Bone Defect by Autologous Mesenchymal Stem Cells and Plasma-Derived Fibrin Impregnated Ceramic Block Results in Early Recovery of Limb Function. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-464511
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464511