A Standardized Critical Size Defect Model in Normal and Osteoporotic Rats to Evaluate Bone Tissue Engineered Constructs
المؤلفون المشاركون
Zeiter, Stephan
Poser, Livia
Alini, Mauro
Matthys, Romano
Schawalder, Peter
Pearce, Simon
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-11
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Tissue engineered constructs should be tested for their efficacy not only in normal but also in osteoporotic bone.
The rat is an established animal model for osteoporosis and is used often for bone healing studies.
In this study a defined and standardized critical size defect model in the rat suitable for screening new tissue engineered constructs in normal and osteoporotic bone is described and validated.
Normal and ovariectomised Wistar rats received a unilateral middiaphyseal 5 mm defect in the femur, which was instrumented with a radiolucent PEEK plate fixed with angular stable titanium screws and left untreated.
All animals were euthanized eight weeks after defect surgery and the bone healing was evaluated using radiographs, computed tomography measurements, and histology.
The developed fixation system provided good stability, even in osteoporotic bone.
The implants and ancillary instruments ensured consistent and facile placement of the PEEK plates.
The untreated defects did not heal without intervention making the model a well-defined and standardized critical size defect model highly useful for evaluating tissue engineered solutions in normal and osteoporotic bone.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Poser, Livia& Matthys, Romano& Schawalder, Peter& Pearce, Simon& Alini, Mauro& Zeiter, Stephan. 2014. A Standardized Critical Size Defect Model in Normal and Osteoporotic Rats to Evaluate Bone Tissue Engineered Constructs. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-464756
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zeiter, Stephan…[et al.]. A Standardized Critical Size Defect Model in Normal and Osteoporotic Rats to Evaluate Bone Tissue Engineered Constructs. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-464756
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Poser, Livia& Matthys, Romano& Schawalder, Peter& Pearce, Simon& Alini, Mauro& Zeiter, Stephan. A Standardized Critical Size Defect Model in Normal and Osteoporotic Rats to Evaluate Bone Tissue Engineered Constructs. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-464756
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-464756
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر