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A Standardized Critical Size Defect Model in Normal and Osteoporotic Rats to Evaluate Bone Tissue Engineered Constructs
Joint Authors
Zeiter, Stephan
Poser, Livia
Alini, Mauro
Matthys, Romano
Schawalder, Peter
Pearce, Simon
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-11
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Tissue engineered constructs should be tested for their efficacy not only in normal but also in osteoporotic bone.
The rat is an established animal model for osteoporosis and is used often for bone healing studies.
In this study a defined and standardized critical size defect model in the rat suitable for screening new tissue engineered constructs in normal and osteoporotic bone is described and validated.
Normal and ovariectomised Wistar rats received a unilateral middiaphyseal 5 mm defect in the femur, which was instrumented with a radiolucent PEEK plate fixed with angular stable titanium screws and left untreated.
All animals were euthanized eight weeks after defect surgery and the bone healing was evaluated using radiographs, computed tomography measurements, and histology.
The developed fixation system provided good stability, even in osteoporotic bone.
The implants and ancillary instruments ensured consistent and facile placement of the PEEK plates.
The untreated defects did not heal without intervention making the model a well-defined and standardized critical size defect model highly useful for evaluating tissue engineered solutions in normal and osteoporotic bone.
American Psychological Association (APA)
Poser, Livia& Matthys, Romano& Schawalder, Peter& Pearce, Simon& Alini, Mauro& Zeiter, Stephan. 2014. A Standardized Critical Size Defect Model in Normal and Osteoporotic Rats to Evaluate Bone Tissue Engineered Constructs. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-464756
Modern Language Association (MLA)
Zeiter, Stephan…[et al.]. A Standardized Critical Size Defect Model in Normal and Osteoporotic Rats to Evaluate Bone Tissue Engineered Constructs. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-464756
American Medical Association (AMA)
Poser, Livia& Matthys, Romano& Schawalder, Peter& Pearce, Simon& Alini, Mauro& Zeiter, Stephan. A Standardized Critical Size Defect Model in Normal and Osteoporotic Rats to Evaluate Bone Tissue Engineered Constructs. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-464756
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464756