Effect of Hachimijiogan against Renal Dysfunction and Involvement of Hypoxia-Inducible Factor-1α in the Remnant Kidney Model
المؤلفون المشاركون
Shibahara, Naotoshi
Koizumi, Keiichi
Tsuneyama, Koichi
Oka, Hiroshi
Goto, Hirozo
Zhou, Yue
Saiki, Ikuo
Shimada, Yutaka
Nakamura, Shin
Sakurai, Hiroaki
Jo, Michiko
Fujimoto, Takako
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-02-24
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
In chronic renal failure, hypoxia of renal tissue is thought to be the common final pathway leading to end-stage renal failure.
In this study the effects of hachimijiogan, a Kampo formula, were studied with respect to hypoxia-inducible factor (HIF).
Using remnant kidney rats, we studied the effects of hachimijiogan on renal function in comparison with angiotensin II receptor blocker.
The result showed that oral administration of hachimijiogan for seven days suppressed urinary protein excretion and urinary 8-OHdG, a marker of antioxidant activity, equally as well as oral administration of candesartan cilexetil.
In contrast, the protein volume of HIF-1α in the renal cortex was not increased in the candesartan cilexetil group, but that in the hachimijiogan group was increased.
In immunohistochemical studies as well, the expression of HIF-1α of the high-dose hachimijiogan group increased compared to that of the control group.
Vascular endothelial growth factor and glucose transporter 1, target genes of HIF-1α, were also increased in the hachimijiogan group.
These results suggest that hachimijiogan produces a protective effect by a mechanism different from that of candesartan cilexetil.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Oka, Hiroshi& Goto, Hirozo& Koizumi, Keiichi& Nakamura, Shin& Tsuneyama, Koichi& Zhou, Yue…[et al.]. 2011. Effect of Hachimijiogan against Renal Dysfunction and Involvement of Hypoxia-Inducible Factor-1α in the Remnant Kidney Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-464761
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Oka, Hiroshi…[et al.]. Effect of Hachimijiogan against Renal Dysfunction and Involvement of Hypoxia-Inducible Factor-1α in the Remnant Kidney Model. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-464761
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Oka, Hiroshi& Goto, Hirozo& Koizumi, Keiichi& Nakamura, Shin& Tsuneyama, Koichi& Zhou, Yue…[et al.]. Effect of Hachimijiogan against Renal Dysfunction and Involvement of Hypoxia-Inducible Factor-1α in the Remnant Kidney Model. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-464761
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-464761
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر