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Effect of Hachimijiogan against Renal Dysfunction and Involvement of Hypoxia-Inducible Factor-1α in the Remnant Kidney Model
Joint Authors
Shibahara, Naotoshi
Koizumi, Keiichi
Tsuneyama, Koichi
Oka, Hiroshi
Goto, Hirozo
Zhou, Yue
Saiki, Ikuo
Shimada, Yutaka
Nakamura, Shin
Sakurai, Hiroaki
Jo, Michiko
Fujimoto, Takako
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
In chronic renal failure, hypoxia of renal tissue is thought to be the common final pathway leading to end-stage renal failure.
In this study the effects of hachimijiogan, a Kampo formula, were studied with respect to hypoxia-inducible factor (HIF).
Using remnant kidney rats, we studied the effects of hachimijiogan on renal function in comparison with angiotensin II receptor blocker.
The result showed that oral administration of hachimijiogan for seven days suppressed urinary protein excretion and urinary 8-OHdG, a marker of antioxidant activity, equally as well as oral administration of candesartan cilexetil.
In contrast, the protein volume of HIF-1α in the renal cortex was not increased in the candesartan cilexetil group, but that in the hachimijiogan group was increased.
In immunohistochemical studies as well, the expression of HIF-1α of the high-dose hachimijiogan group increased compared to that of the control group.
Vascular endothelial growth factor and glucose transporter 1, target genes of HIF-1α, were also increased in the hachimijiogan group.
These results suggest that hachimijiogan produces a protective effect by a mechanism different from that of candesartan cilexetil.
American Psychological Association (APA)
Oka, Hiroshi& Goto, Hirozo& Koizumi, Keiichi& Nakamura, Shin& Tsuneyama, Koichi& Zhou, Yue…[et al.]. 2011. Effect of Hachimijiogan against Renal Dysfunction and Involvement of Hypoxia-Inducible Factor-1α in the Remnant Kidney Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-464761
Modern Language Association (MLA)
Oka, Hiroshi…[et al.]. Effect of Hachimijiogan against Renal Dysfunction and Involvement of Hypoxia-Inducible Factor-1α in the Remnant Kidney Model. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-464761
American Medical Association (AMA)
Oka, Hiroshi& Goto, Hirozo& Koizumi, Keiichi& Nakamura, Shin& Tsuneyama, Koichi& Zhou, Yue…[et al.]. Effect of Hachimijiogan against Renal Dysfunction and Involvement of Hypoxia-Inducible Factor-1α in the Remnant Kidney Model. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-464761
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464761