Effect of Hachimijiogan against Renal Dysfunction and Involvement of Hypoxia-Inducible Factor-1α in the Remnant Kidney Model

Joint Authors

Shibahara, Naotoshi
Koizumi, Keiichi
Tsuneyama, Koichi
Oka, Hiroshi
Goto, Hirozo
Zhou, Yue
Saiki, Ikuo
Shimada, Yutaka
Nakamura, Shin
Sakurai, Hiroaki
Jo, Michiko
Fujimoto, Takako

Source

Evidence-Based Complementary and Alternative Medicine

Issue

Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-02-24

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Medicine

Abstract EN

In chronic renal failure, hypoxia of renal tissue is thought to be the common final pathway leading to end-stage renal failure.

In this study the effects of hachimijiogan, a Kampo formula, were studied with respect to hypoxia-inducible factor (HIF).

Using remnant kidney rats, we studied the effects of hachimijiogan on renal function in comparison with angiotensin II receptor blocker.

The result showed that oral administration of hachimijiogan for seven days suppressed urinary protein excretion and urinary 8-OHdG, a marker of antioxidant activity, equally as well as oral administration of candesartan cilexetil.

In contrast, the protein volume of HIF-1α in the renal cortex was not increased in the candesartan cilexetil group, but that in the hachimijiogan group was increased.

In immunohistochemical studies as well, the expression of HIF-1α of the high-dose hachimijiogan group increased compared to that of the control group.

Vascular endothelial growth factor and glucose transporter 1, target genes of HIF-1α, were also increased in the hachimijiogan group.

These results suggest that hachimijiogan produces a protective effect by a mechanism different from that of candesartan cilexetil.

American Psychological Association (APA)

Oka, Hiroshi& Goto, Hirozo& Koizumi, Keiichi& Nakamura, Shin& Tsuneyama, Koichi& Zhou, Yue…[et al.]. 2011. Effect of Hachimijiogan against Renal Dysfunction and Involvement of Hypoxia-Inducible Factor-1α in the Remnant Kidney Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-464761

Modern Language Association (MLA)

Oka, Hiroshi…[et al.]. Effect of Hachimijiogan against Renal Dysfunction and Involvement of Hypoxia-Inducible Factor-1α in the Remnant Kidney Model. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-464761

American Medical Association (AMA)

Oka, Hiroshi& Goto, Hirozo& Koizumi, Keiichi& Nakamura, Shin& Tsuneyama, Koichi& Zhou, Yue…[et al.]. Effect of Hachimijiogan against Renal Dysfunction and Involvement of Hypoxia-Inducible Factor-1α in the Remnant Kidney Model. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-464761

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-464761