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Exploratory Pharmacokinetics of Geniposide in Rat Model of Cerebral Ischemia Orally Administered with or without Baicalin andor Berberine
المؤلفون المشاركون
Zhu, Huaxu
Zeng, Mingfei
Zhou, Jing
Wang, Wenzhe
Shi, Feiyan
Pan, Linmei
Zhang, Meng
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-03
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Huang-Lian-Jie-Du-Tang (HLJDT), a classical Chinese prescription, has been clinically employed to treat cerebral ischemia for thousands of years.
Geniposide is the major active ingredient in HLJDT.
The aim is to investigate the comparative evaluations on pharmacokinetics of geniposide in MCAO rats in pure geniposide, geniposide : berberine, and geniposide : berberine : baicalin.
Obviously, the proportions of geniposide : berberine, geniposide : baicalin, and geniposide : berberine : baicalin were determined according to HLJDT.
In our study, the cerebral ischemia model was reproduced by suture method in rats.
The MCAO rats were randomly assigned to four therapy groups and orally administered with different prescription proportions of pure geniposide, geniposide : berberine, geniposide : baicalin, and geniposide : berberine : baicalin, respectively.
The concentrations of geniposide in rat serum were determined using HPLC, and main pharmacokinetic parameters were investigated.
The results indicated that the pharmacokinetics of geniposide in rat serum was nonlinear and there were significant differences between different groups.
Berberine might hardly affect the absorption of geniposide, and baicalin could increase the absorption ability of geniposide.
Meanwhile, berberine could decrease the absorption increase of baicalin on geniposide.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pan, Linmei& Wang, Wenzhe& Shi, Feiyan& Zhou, Jing& Zhang, Meng& Zhu, Huaxu…[et al.]. 2013. Exploratory Pharmacokinetics of Geniposide in Rat Model of Cerebral Ischemia Orally Administered with or without Baicalin andor Berberine. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-464846
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pan, Linmei…[et al.]. Exploratory Pharmacokinetics of Geniposide in Rat Model of Cerebral Ischemia Orally Administered with or without Baicalin andor Berberine. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-464846
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pan, Linmei& Wang, Wenzhe& Shi, Feiyan& Zhou, Jing& Zhang, Meng& Zhu, Huaxu…[et al.]. Exploratory Pharmacokinetics of Geniposide in Rat Model of Cerebral Ischemia Orally Administered with or without Baicalin andor Berberine. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-464846
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-464846
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