Exploratory Pharmacokinetics of Geniposide in Rat Model of Cerebral Ischemia Orally Administered with or without Baicalin andor Berberine
Joint Authors
Zhu, Huaxu
Zeng, Mingfei
Zhou, Jing
Wang, Wenzhe
Shi, Feiyan
Pan, Linmei
Zhang, Meng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Huang-Lian-Jie-Du-Tang (HLJDT), a classical Chinese prescription, has been clinically employed to treat cerebral ischemia for thousands of years.
Geniposide is the major active ingredient in HLJDT.
The aim is to investigate the comparative evaluations on pharmacokinetics of geniposide in MCAO rats in pure geniposide, geniposide : berberine, and geniposide : berberine : baicalin.
Obviously, the proportions of geniposide : berberine, geniposide : baicalin, and geniposide : berberine : baicalin were determined according to HLJDT.
In our study, the cerebral ischemia model was reproduced by suture method in rats.
The MCAO rats were randomly assigned to four therapy groups and orally administered with different prescription proportions of pure geniposide, geniposide : berberine, geniposide : baicalin, and geniposide : berberine : baicalin, respectively.
The concentrations of geniposide in rat serum were determined using HPLC, and main pharmacokinetic parameters were investigated.
The results indicated that the pharmacokinetics of geniposide in rat serum was nonlinear and there were significant differences between different groups.
Berberine might hardly affect the absorption of geniposide, and baicalin could increase the absorption ability of geniposide.
Meanwhile, berberine could decrease the absorption increase of baicalin on geniposide.
American Psychological Association (APA)
Pan, Linmei& Wang, Wenzhe& Shi, Feiyan& Zhou, Jing& Zhang, Meng& Zhu, Huaxu…[et al.]. 2013. Exploratory Pharmacokinetics of Geniposide in Rat Model of Cerebral Ischemia Orally Administered with or without Baicalin andor Berberine. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-464846
Modern Language Association (MLA)
Pan, Linmei…[et al.]. Exploratory Pharmacokinetics of Geniposide in Rat Model of Cerebral Ischemia Orally Administered with or without Baicalin andor Berberine. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-464846
American Medical Association (AMA)
Pan, Linmei& Wang, Wenzhe& Shi, Feiyan& Zhou, Jing& Zhang, Meng& Zhu, Huaxu…[et al.]. Exploratory Pharmacokinetics of Geniposide in Rat Model of Cerebral Ischemia Orally Administered with or without Baicalin andor Berberine. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-464846
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464846