Prenylated Flavonoids from Morus alba L. Cause Inhibition of G1S Transition in THP-1 Human Leukemia Cells and Prevent the Lipopolysaccharide-Induced Inflammatory Response
المؤلفون المشاركون
Šmejkal, Karel
Kollar, Peter
Závalová, Veronika Müller
Bárta, Tomáš
Talhouk, Rabih
Artinian, Shushan
Souček, Karel
Hošek, Jan
Suchý, Pavel
Hampl, Aleš
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-05-20
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Morus alba L.
(MA) is a natural source of many compounds with different biological effects.
It has been described to possess anti-inflammatory, antioxidant, and hepatoprotective activities.
The aim of this study was to evaluate cytotoxicity of three flavonoids isolated from MA (kuwanon E, cudraflavone B, and 4′-O-methylkuwanon E) and to determine their effects on proliferation of THP-1 cells, and on cell cycle progression of cancer cells.
Anti-inflammatory effects were also determined for all three given flavonoids.
Methods used in the study included quantification of cells by hemocytometer and WST-1 assays, flow cytometry, western blotting, ELISA, and zymography.
From the three compounds tested, cudraflavone B showed the strongest effects on cell cycle progression and viability of tumor and/or immortalized cells and also on inflammatory response of macrophage-like cells.
Kuwanon E and 4′-O-methylkuwanon E exerted more sophisticated rather than direct toxic effect on used cell types.
Our data indicate that mechanisms different from stress-related or apoptotic signaling pathways are involved in the action of these compounds.
Although further studies are required to precisely define the mechanisms of MA flavonoid action in human cancer and macrophage-like cells, here we demonstrate their effects combining antiproliferative and anti-inflammatory activities, respectively.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kollar, Peter& Bárta, Tomáš& Hošek, Jan& Souček, Karel& Závalová, Veronika Müller& Artinian, Shushan…[et al.]. 2013. Prenylated Flavonoids from Morus alba L. Cause Inhibition of G1S Transition in THP-1 Human Leukemia Cells and Prevent the Lipopolysaccharide-Induced Inflammatory Response. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-464919
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kollar, Peter…[et al.]. Prenylated Flavonoids from Morus alba L. Cause Inhibition of G1S Transition in THP-1 Human Leukemia Cells and Prevent the Lipopolysaccharide-Induced Inflammatory Response. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-464919
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kollar, Peter& Bárta, Tomáš& Hošek, Jan& Souček, Karel& Závalová, Veronika Müller& Artinian, Shushan…[et al.]. Prenylated Flavonoids from Morus alba L. Cause Inhibition of G1S Transition in THP-1 Human Leukemia Cells and Prevent the Lipopolysaccharide-Induced Inflammatory Response. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-464919
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-464919
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر