Prenylated Flavonoids from Morus alba L. Cause Inhibition of G1S Transition in THP-1 Human Leukemia Cells and Prevent the Lipopolysaccharide-Induced Inflammatory Response
Joint Authors
Šmejkal, Karel
Kollar, Peter
Závalová, Veronika Müller
Bárta, Tomáš
Talhouk, Rabih
Artinian, Shushan
Souček, Karel
Hošek, Jan
Suchý, Pavel
Hampl, Aleš
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-20
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Morus alba L.
(MA) is a natural source of many compounds with different biological effects.
It has been described to possess anti-inflammatory, antioxidant, and hepatoprotective activities.
The aim of this study was to evaluate cytotoxicity of three flavonoids isolated from MA (kuwanon E, cudraflavone B, and 4′-O-methylkuwanon E) and to determine their effects on proliferation of THP-1 cells, and on cell cycle progression of cancer cells.
Anti-inflammatory effects were also determined for all three given flavonoids.
Methods used in the study included quantification of cells by hemocytometer and WST-1 assays, flow cytometry, western blotting, ELISA, and zymography.
From the three compounds tested, cudraflavone B showed the strongest effects on cell cycle progression and viability of tumor and/or immortalized cells and also on inflammatory response of macrophage-like cells.
Kuwanon E and 4′-O-methylkuwanon E exerted more sophisticated rather than direct toxic effect on used cell types.
Our data indicate that mechanisms different from stress-related or apoptotic signaling pathways are involved in the action of these compounds.
Although further studies are required to precisely define the mechanisms of MA flavonoid action in human cancer and macrophage-like cells, here we demonstrate their effects combining antiproliferative and anti-inflammatory activities, respectively.
American Psychological Association (APA)
Kollar, Peter& Bárta, Tomáš& Hošek, Jan& Souček, Karel& Závalová, Veronika Müller& Artinian, Shushan…[et al.]. 2013. Prenylated Flavonoids from Morus alba L. Cause Inhibition of G1S Transition in THP-1 Human Leukemia Cells and Prevent the Lipopolysaccharide-Induced Inflammatory Response. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-464919
Modern Language Association (MLA)
Kollar, Peter…[et al.]. Prenylated Flavonoids from Morus alba L. Cause Inhibition of G1S Transition in THP-1 Human Leukemia Cells and Prevent the Lipopolysaccharide-Induced Inflammatory Response. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-464919
American Medical Association (AMA)
Kollar, Peter& Bárta, Tomáš& Hošek, Jan& Souček, Karel& Závalová, Veronika Müller& Artinian, Shushan…[et al.]. Prenylated Flavonoids from Morus alba L. Cause Inhibition of G1S Transition in THP-1 Human Leukemia Cells and Prevent the Lipopolysaccharide-Induced Inflammatory Response. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-464919
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464919