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Association of Levels of Antibodies from Patients with Inflammatory Bowel Disease with Extracellular Proteins of Food and Probiotic Bacteria
المؤلفون المشاركون
López, Patricia
Hevia, Arancha
Margolles, Abelardo
Jacquot, Claudine
Urdaci, María C.
Sánchez, Borja
Suárez, Ana
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-04
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Inflammatory bowel disease (IBD) is an autoimmune disease characterized by a chronic inflammation of the gastrointestinal tract mucosa and is related to an abnormal immune response to commensal bacteria.
Our aim of the present work has been to explore the levels of antibodies (IgG and IgA) raised against extracellular proteins produced by LAB and its association with IBD.
We analyzed, by Western-blot and ELISA, the presence of serum antibodies (IgA and IgG) developed against extracellular protein fractions produced by different food bacteria from the genera Bifidobacterium and Lactobacillus.
We used a sera collection consisting of healthy individuals (HC, n=50), Crohn's disease patients (CD, n=37), and ulcerative colitis patients (UC, n=15).
Levels of IgA antibodies developed against a cell-wall hydrolase from Lactobacillus casei subsp.
rhamnosus GG (CWH) were significantly higher in the IBD group (P<0.002; n=52).
The specificity of our measurements was confirmed by measuring IgA antibodies developed against the CWH peptide 365-VNTSNQTAAVSAS-377.
IBD patients appeared to have different immune response to food bacteria.
This paper sets the basis for developing systems for early detection of IBD, based on the association of high levels of antibodies developed against extracellular proteins from food and probiotic bacteria.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hevia, Arancha& López, Patricia& Suárez, Ana& Jacquot, Claudine& Urdaci, María C.& Margolles, Abelardo…[et al.]. 2014. Association of Levels of Antibodies from Patients with Inflammatory Bowel Disease with Extracellular Proteins of Food and Probiotic Bacteria. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-464987
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hevia, Arancha…[et al.]. Association of Levels of Antibodies from Patients with Inflammatory Bowel Disease with Extracellular Proteins of Food and Probiotic Bacteria. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-464987
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hevia, Arancha& López, Patricia& Suárez, Ana& Jacquot, Claudine& Urdaci, María C.& Margolles, Abelardo…[et al.]. Association of Levels of Antibodies from Patients with Inflammatory Bowel Disease with Extracellular Proteins of Food and Probiotic Bacteria. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-464987
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-464987
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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