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Association of Levels of Antibodies from Patients with Inflammatory Bowel Disease with Extracellular Proteins of Food and Probiotic Bacteria
Joint Authors
López, Patricia
Hevia, Arancha
Margolles, Abelardo
Jacquot, Claudine
Urdaci, María C.
Sánchez, Borja
Suárez, Ana
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Inflammatory bowel disease (IBD) is an autoimmune disease characterized by a chronic inflammation of the gastrointestinal tract mucosa and is related to an abnormal immune response to commensal bacteria.
Our aim of the present work has been to explore the levels of antibodies (IgG and IgA) raised against extracellular proteins produced by LAB and its association with IBD.
We analyzed, by Western-blot and ELISA, the presence of serum antibodies (IgA and IgG) developed against extracellular protein fractions produced by different food bacteria from the genera Bifidobacterium and Lactobacillus.
We used a sera collection consisting of healthy individuals (HC, n=50), Crohn's disease patients (CD, n=37), and ulcerative colitis patients (UC, n=15).
Levels of IgA antibodies developed against a cell-wall hydrolase from Lactobacillus casei subsp.
rhamnosus GG (CWH) were significantly higher in the IBD group (P<0.002; n=52).
The specificity of our measurements was confirmed by measuring IgA antibodies developed against the CWH peptide 365-VNTSNQTAAVSAS-377.
IBD patients appeared to have different immune response to food bacteria.
This paper sets the basis for developing systems for early detection of IBD, based on the association of high levels of antibodies developed against extracellular proteins from food and probiotic bacteria.
American Psychological Association (APA)
Hevia, Arancha& López, Patricia& Suárez, Ana& Jacquot, Claudine& Urdaci, María C.& Margolles, Abelardo…[et al.]. 2014. Association of Levels of Antibodies from Patients with Inflammatory Bowel Disease with Extracellular Proteins of Food and Probiotic Bacteria. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-464987
Modern Language Association (MLA)
Hevia, Arancha…[et al.]. Association of Levels of Antibodies from Patients with Inflammatory Bowel Disease with Extracellular Proteins of Food and Probiotic Bacteria. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-464987
American Medical Association (AMA)
Hevia, Arancha& López, Patricia& Suárez, Ana& Jacquot, Claudine& Urdaci, María C.& Margolles, Abelardo…[et al.]. Association of Levels of Antibodies from Patients with Inflammatory Bowel Disease with Extracellular Proteins of Food and Probiotic Bacteria. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-464987
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464987