Helical Tomotherapy Combined with Capecitabine in the Preoperative Treatment of Locally Advanced Rectal Cancer
المؤلفون المشاركون
Huang, Chih-Jen
Wu, Chan-Han
Ma, Cheng-Jen
Wang, Jaw-Yuan
Huang, Chun-Ming
Yeh, Yung-Sung
Tsai, Hsiang-Lin
Huang, Ming-Yii
Lu, Chien-Yu
Chen, Chin-Fan
Chai, Chee-Yin
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-06
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The aim of this study was to evaluate the efficacy of helical tomotherapy plus capecitabine as a preoperative chemoradiotherapy (CRT) in patients with locally advanced rectal cancer (LARC).
Thirty-six LARC patients receiving preoperative CRT were analyzed.
Radiotherapy (RT) consisted of 45 Gy to the regional lymph nodes and simultaneous-integrated boost (SIB) 50.4 Gy to the tumor, 5 days/week for 5 weeks.
Chemotherapy consisted of capecitabine 850 mg/m2, twice daily, during the RT days.
Patients underwent surgery 6–8 weeks after completion of CRT.
Information was collected for patient characteristics, treatment response, and acute and late toxicities.
Grade 3/4 (G3+) toxicities occurred in 11.1% of patients (4/36).
Sphincter preservation rate was 85.2% (23/27).
Five patients (14.3%) achieved pathological complete response.
Tumor, nodal, and ypT0-2N0 downstaging were noted in 60% (21/35), 69.6% (16/23), and 57.1% (20/35).
Tumor regression grade 2~4 was achieved in 28 patients (80%).
After a median follow-up time of 35 months, the most common G3+ late morbidity was ileus and fistula (5.7%, 2/35).
The study showed that capecitabine plus helical tomotherapy with an SIB is feasible in treatment of LARC.
The treatment modality can achieve a very encouraging sphincter preservation rate and a favorable ypT0-2N0 downstaging rate without excessive toxicity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Huang, Ming-Yii& Chen, Chin-Fan& Huang, Chun-Ming& Tsai, Hsiang-Lin& Yeh, Yung-Sung& Ma, Cheng-Jen…[et al.]. 2014. Helical Tomotherapy Combined with Capecitabine in the Preoperative Treatment of Locally Advanced Rectal Cancer. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-465097
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Huang, Ming-Yii…[et al.]. Helical Tomotherapy Combined with Capecitabine in the Preoperative Treatment of Locally Advanced Rectal Cancer. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-465097
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Huang, Ming-Yii& Chen, Chin-Fan& Huang, Chun-Ming& Tsai, Hsiang-Lin& Yeh, Yung-Sung& Ma, Cheng-Jen…[et al.]. Helical Tomotherapy Combined with Capecitabine in the Preoperative Treatment of Locally Advanced Rectal Cancer. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-465097
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-465097
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر