Helical Tomotherapy Combined with Capecitabine in the Preoperative Treatment of Locally Advanced Rectal Cancer
Joint Authors
Huang, Chih-Jen
Wu, Chan-Han
Ma, Cheng-Jen
Wang, Jaw-Yuan
Huang, Chun-Ming
Yeh, Yung-Sung
Tsai, Hsiang-Lin
Huang, Ming-Yii
Lu, Chien-Yu
Chen, Chin-Fan
Chai, Chee-Yin
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-06
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The aim of this study was to evaluate the efficacy of helical tomotherapy plus capecitabine as a preoperative chemoradiotherapy (CRT) in patients with locally advanced rectal cancer (LARC).
Thirty-six LARC patients receiving preoperative CRT were analyzed.
Radiotherapy (RT) consisted of 45 Gy to the regional lymph nodes and simultaneous-integrated boost (SIB) 50.4 Gy to the tumor, 5 days/week for 5 weeks.
Chemotherapy consisted of capecitabine 850 mg/m2, twice daily, during the RT days.
Patients underwent surgery 6–8 weeks after completion of CRT.
Information was collected for patient characteristics, treatment response, and acute and late toxicities.
Grade 3/4 (G3+) toxicities occurred in 11.1% of patients (4/36).
Sphincter preservation rate was 85.2% (23/27).
Five patients (14.3%) achieved pathological complete response.
Tumor, nodal, and ypT0-2N0 downstaging were noted in 60% (21/35), 69.6% (16/23), and 57.1% (20/35).
Tumor regression grade 2~4 was achieved in 28 patients (80%).
After a median follow-up time of 35 months, the most common G3+ late morbidity was ileus and fistula (5.7%, 2/35).
The study showed that capecitabine plus helical tomotherapy with an SIB is feasible in treatment of LARC.
The treatment modality can achieve a very encouraging sphincter preservation rate and a favorable ypT0-2N0 downstaging rate without excessive toxicity.
American Psychological Association (APA)
Huang, Ming-Yii& Chen, Chin-Fan& Huang, Chun-Ming& Tsai, Hsiang-Lin& Yeh, Yung-Sung& Ma, Cheng-Jen…[et al.]. 2014. Helical Tomotherapy Combined with Capecitabine in the Preoperative Treatment of Locally Advanced Rectal Cancer. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-465097
Modern Language Association (MLA)
Huang, Ming-Yii…[et al.]. Helical Tomotherapy Combined with Capecitabine in the Preoperative Treatment of Locally Advanced Rectal Cancer. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-465097
American Medical Association (AMA)
Huang, Ming-Yii& Chen, Chin-Fan& Huang, Chun-Ming& Tsai, Hsiang-Lin& Yeh, Yung-Sung& Ma, Cheng-Jen…[et al.]. Helical Tomotherapy Combined with Capecitabine in the Preoperative Treatment of Locally Advanced Rectal Cancer. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-465097
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465097