The Curative and Prophylactic Effects of Xylopic Acid on Plasmodium berghei Infection in Mice

المؤلفون المشاركون

Ameyaw, E. O.
Aboagye, B.
Woode, E.
Kyei, S.
Donfack, J. H.
Boampong, J. N.
Asare, K.

المصدر

Journal of Parasitology Research

العدد

المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2013-07-18

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

علم الحيوان
الأمراض

الملخص EN

Efforts have been intensified to search for more effective antimalarial agents because of the observed failure of some artemisinin-based combination therapy (ACT) treatments of malaria in Ghana.

Xylopic acid, a pure compound isolated from the fruits of the Xylopia aethiopica, was investigated to establish its attributable prophylactic, curative antimalarial, and antipyretic properties.

The antimalarial properties were determined by employing xylopic acid (10–100 mg/kg) in ICR mice infected with Plasmodium berghei.

Xylopic acid exerted significant (P<0.05) effects on P.

berghei infection similar to artemether/lumefantrine, the standard drug.

Furthermore, it significantly (P<0.05) reduced the lipopolysaccharide- (LPS-) induced fever in Sprague-Dawley rats similar to prednisolone.

Xylopic acid therefore possesses prophylactic and curative antimalarial as well as antipyretic properties which makes it an ideal antimalarial agent.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Boampong, J. N.& Ameyaw, E. O.& Aboagye, B.& Asare, K.& Kyei, S.& Donfack, J. H.…[et al.]. 2013. The Curative and Prophylactic Effects of Xylopic Acid on Plasmodium berghei Infection in Mice. Journal of Parasitology Research،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-465376

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Boampong, J. N.…[et al.]. The Curative and Prophylactic Effects of Xylopic Acid on Plasmodium berghei Infection in Mice. Journal of Parasitology Research No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-465376

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Boampong, J. N.& Ameyaw, E. O.& Aboagye, B.& Asare, K.& Kyei, S.& Donfack, J. H.…[et al.]. The Curative and Prophylactic Effects of Xylopic Acid on Plasmodium berghei Infection in Mice. Journal of Parasitology Research. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-465376

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-465376