The Curative and Prophylactic Effects of Xylopic Acid on Plasmodium berghei Infection in Mice
Joint Authors
Ameyaw, E. O.
Aboagye, B.
Woode, E.
Kyei, S.
Donfack, J. H.
Boampong, J. N.
Asare, K.
Source
Journal of Parasitology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Efforts have been intensified to search for more effective antimalarial agents because of the observed failure of some artemisinin-based combination therapy (ACT) treatments of malaria in Ghana.
Xylopic acid, a pure compound isolated from the fruits of the Xylopia aethiopica, was investigated to establish its attributable prophylactic, curative antimalarial, and antipyretic properties.
The antimalarial properties were determined by employing xylopic acid (10–100 mg/kg) in ICR mice infected with Plasmodium berghei.
Xylopic acid exerted significant (P<0.05) effects on P.
berghei infection similar to artemether/lumefantrine, the standard drug.
Furthermore, it significantly (P<0.05) reduced the lipopolysaccharide- (LPS-) induced fever in Sprague-Dawley rats similar to prednisolone.
Xylopic acid therefore possesses prophylactic and curative antimalarial as well as antipyretic properties which makes it an ideal antimalarial agent.
American Psychological Association (APA)
Boampong, J. N.& Ameyaw, E. O.& Aboagye, B.& Asare, K.& Kyei, S.& Donfack, J. H.…[et al.]. 2013. The Curative and Prophylactic Effects of Xylopic Acid on Plasmodium berghei Infection in Mice. Journal of Parasitology Research،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-465376
Modern Language Association (MLA)
Boampong, J. N.…[et al.]. The Curative and Prophylactic Effects of Xylopic Acid on Plasmodium berghei Infection in Mice. Journal of Parasitology Research No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-465376
American Medical Association (AMA)
Boampong, J. N.& Ameyaw, E. O.& Aboagye, B.& Asare, K.& Kyei, S.& Donfack, J. H.…[et al.]. The Curative and Prophylactic Effects of Xylopic Acid on Plasmodium berghei Infection in Mice. Journal of Parasitology Research. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-465376
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465376