CpG Island Methylation, Microsatellite Instability, and BRAF Mutations and Their Clinical Application in the Treatment of Colon Cancer

المؤلفون المشاركون

Wu, Christina
Bekaii-Saab, Tanios

المصدر

Chemotherapy Research and Practice

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2012-06-26

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

علم الصيدلة

الملخص EN

There have been significant developments in colon cancer research over the last few years, enabling us to better characterize tumors individually and classifying them according to certain molecular or genetic features.

Currently, we are able to use KRAS mutational status as a guide to therapy with anti-epidermal growth factor receptor antibodies.

Other molecular features under research include BRAF mutation, microsatellite instability, and CpG island methylation.

These three molecular features are often associated with tumors that have overlapping phenotypes and can be present simultaneously in the same tumor.

However, they carry different prognostic and predictive qualities, making analysis of their interaction relatively complex.

Much research thus far has examined the clinical relevance of microsatellite instability in helping determine prognosis and the predictive value of adjuvant 5-fluorouracil chemotherapy in stages II and III colon cancers.

BRAF mutation appears to be a biomarker for poor prognosis.

CpG island methylation is tightly associated with microsatellite instable tumors and BRAF mutation, but its clinical utility remains uncertain.

Hereby, we examine preclinical and clinical data that supports the utilization of all three phenotypes in future research applied to clinical practice.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Wu, Christina& Bekaii-Saab, Tanios. 2012. CpG Island Methylation, Microsatellite Instability, and BRAF Mutations and Their Clinical Application in the Treatment of Colon Cancer. Chemotherapy Research and Practice،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-465667

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Wu, Christina& Bekaii-Saab, Tanios. CpG Island Methylation, Microsatellite Instability, and BRAF Mutations and Their Clinical Application in the Treatment of Colon Cancer. Chemotherapy Research and Practice No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-465667

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Wu, Christina& Bekaii-Saab, Tanios. CpG Island Methylation, Microsatellite Instability, and BRAF Mutations and Their Clinical Application in the Treatment of Colon Cancer. Chemotherapy Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-465667

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-465667