CpG Island Methylation, Microsatellite Instability, and BRAF Mutations and Their Clinical Application in the Treatment of Colon Cancer
Joint Authors
Wu, Christina
Bekaii-Saab, Tanios
Source
Chemotherapy Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
There have been significant developments in colon cancer research over the last few years, enabling us to better characterize tumors individually and classifying them according to certain molecular or genetic features.
Currently, we are able to use KRAS mutational status as a guide to therapy with anti-epidermal growth factor receptor antibodies.
Other molecular features under research include BRAF mutation, microsatellite instability, and CpG island methylation.
These three molecular features are often associated with tumors that have overlapping phenotypes and can be present simultaneously in the same tumor.
However, they carry different prognostic and predictive qualities, making analysis of their interaction relatively complex.
Much research thus far has examined the clinical relevance of microsatellite instability in helping determine prognosis and the predictive value of adjuvant 5-fluorouracil chemotherapy in stages II and III colon cancers.
BRAF mutation appears to be a biomarker for poor prognosis.
CpG island methylation is tightly associated with microsatellite instable tumors and BRAF mutation, but its clinical utility remains uncertain.
Hereby, we examine preclinical and clinical data that supports the utilization of all three phenotypes in future research applied to clinical practice.
American Psychological Association (APA)
Wu, Christina& Bekaii-Saab, Tanios. 2012. CpG Island Methylation, Microsatellite Instability, and BRAF Mutations and Their Clinical Application in the Treatment of Colon Cancer. Chemotherapy Research and Practice،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-465667
Modern Language Association (MLA)
Wu, Christina& Bekaii-Saab, Tanios. CpG Island Methylation, Microsatellite Instability, and BRAF Mutations and Their Clinical Application in the Treatment of Colon Cancer. Chemotherapy Research and Practice No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-465667
American Medical Association (AMA)
Wu, Christina& Bekaii-Saab, Tanios. CpG Island Methylation, Microsatellite Instability, and BRAF Mutations and Their Clinical Application in the Treatment of Colon Cancer. Chemotherapy Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-465667
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465667