Biomarkers of Adverse Response to Mercury : Histopathology versus Thioredoxin Reductase Activity
المؤلفون المشاركون
Canário, João
Branco, Vasco
Ramos, Paula
Carvalho, Cristina
Lu, Jun
Holmgren, Arne
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-07-19
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Exposure to mercury is normally assessed by measuring its accumulation in hair, blood or urine.
Currently, the biomarkers of effect that have been proposed for mercurials, such as coproporphyrines or oxidative stress markers, are not sensitive enough and lack specificity.
Selenium and selenoproteins are important targets for mercury and thioredoxin reductase (TrxR) in particular was shown to be very sensitive to mercury compounds both in vitro and in vivo.
In this study we looked into the relation between the inhibition of thioredoxin reductase (TrxR) activity and histopathological changes caused by exposure to mercurials.
Juvenile zeabra-seabreams were exposed to Hg2+ or MeHg for 28 days and histopathological changes were analyzed in the liver and kidney as well as TrxR activity.
Both mercurials caused histopathological changes in liver and kidney, albeit Hg2+ caused more extensive and severe lesions.
Likewise, both mercurials decreased TrxR activity, being Hg2+ a stronger inhibitor.
Co-exposure to Hg2+ and Se fully prevented TrxR inhibition in the liver and reduced the severity of lesions in the organ.
These results show that upon exposure to mercurials, histopathological alterations correlate with the level of TrxR activity and point to the potential use of this enzyme as a biomarker of mercury toxicity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Branco, Vasco& Ramos, Paula& Canário, João& Lu, Jun& Holmgren, Arne& Carvalho, Cristina. 2012. Biomarkers of Adverse Response to Mercury : Histopathology versus Thioredoxin Reductase Activity. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-465768
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Branco, Vasco…[et al.]. Biomarkers of Adverse Response to Mercury : Histopathology versus Thioredoxin Reductase Activity. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-465768
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Branco, Vasco& Ramos, Paula& Canário, João& Lu, Jun& Holmgren, Arne& Carvalho, Cristina. Biomarkers of Adverse Response to Mercury : Histopathology versus Thioredoxin Reductase Activity. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-465768
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-465768
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر