Biomarkers of Adverse Response to Mercury : Histopathology versus Thioredoxin Reductase Activity
Joint Authors
Canário, João
Branco, Vasco
Ramos, Paula
Carvalho, Cristina
Lu, Jun
Holmgren, Arne
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Exposure to mercury is normally assessed by measuring its accumulation in hair, blood or urine.
Currently, the biomarkers of effect that have been proposed for mercurials, such as coproporphyrines or oxidative stress markers, are not sensitive enough and lack specificity.
Selenium and selenoproteins are important targets for mercury and thioredoxin reductase (TrxR) in particular was shown to be very sensitive to mercury compounds both in vitro and in vivo.
In this study we looked into the relation between the inhibition of thioredoxin reductase (TrxR) activity and histopathological changes caused by exposure to mercurials.
Juvenile zeabra-seabreams were exposed to Hg2+ or MeHg for 28 days and histopathological changes were analyzed in the liver and kidney as well as TrxR activity.
Both mercurials caused histopathological changes in liver and kidney, albeit Hg2+ caused more extensive and severe lesions.
Likewise, both mercurials decreased TrxR activity, being Hg2+ a stronger inhibitor.
Co-exposure to Hg2+ and Se fully prevented TrxR inhibition in the liver and reduced the severity of lesions in the organ.
These results show that upon exposure to mercurials, histopathological alterations correlate with the level of TrxR activity and point to the potential use of this enzyme as a biomarker of mercury toxicity.
American Psychological Association (APA)
Branco, Vasco& Ramos, Paula& Canário, João& Lu, Jun& Holmgren, Arne& Carvalho, Cristina. 2012. Biomarkers of Adverse Response to Mercury : Histopathology versus Thioredoxin Reductase Activity. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-465768
Modern Language Association (MLA)
Branco, Vasco…[et al.]. Biomarkers of Adverse Response to Mercury : Histopathology versus Thioredoxin Reductase Activity. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-465768
American Medical Association (AMA)
Branco, Vasco& Ramos, Paula& Canário, João& Lu, Jun& Holmgren, Arne& Carvalho, Cristina. Biomarkers of Adverse Response to Mercury : Histopathology versus Thioredoxin Reductase Activity. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-465768
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465768